International Journal of Current Pharmaceutical Research最新文献

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A STUDY TO ASSESS THE ATTITUDE OF MEDICAL STUDENTS TOWARDS LEARNING COMMUNICATION SKILLS IN A TEACHING HOSPITAL IN ANDHRA PRADESH 评估安得拉邦教学医院医学生对学习沟通技巧的态度的研究
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4021
R. A. Latha, M. A. Farhana, S. S. Sonia, N. M. Riyaz, B. S. B. Mallika
{"title":"A STUDY TO ASSESS THE ATTITUDE OF MEDICAL STUDENTS TOWARDS LEARNING COMMUNICATION SKILLS IN A TEACHING HOSPITAL IN ANDHRA PRADESH","authors":"R. A. Latha, M. A. Farhana, S. S. Sonia, N. M. Riyaz, B. S. B. Mallika","doi":"10.22159/ijcpr.2024v16i1.4021","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4021","url":null,"abstract":"Objective: Communication plays an essential role in present era of medical and health system where doctor should maintain good interpersonal relationship with patients. Teaching of communication skills to medical students as a part of the curriculum has gained importance in recent past. This study was conducted to assess attitude of medical students towards learning communication skills. \u0000Methods: Prior institutional ethical committee approval and prior informed consent obtained from participants. Study conducted among medical students of second and third year MBBS. Students were given a questionnaire (google forms). Questionnaire consisted of 26 items related to positive and negative attitude; 13 items in each subscale. Responses received were entered and analysed in Microsoft excel. \u0000Results: Total of 300 students participated, with a response rate of 76%. 132(57.9%) students were second year and 96(42.1%) were third year. 159(69.7%) students were females and 69(30.3%) were males. Reliability of scale was calculated using Cronbach’s Alpha, 0.859 for PAS and 0.704 for NAS; which were good and acceptable values. Better positive attitude scores (52.34±6.03) observed over negative attitude scores (40.07±6.40), implies students having a positive attitude towards learning communication skills. There were no significant differences between scores when compared between males and females and between second and third year MBBS students. \u0000Conclusion: Results of study emphasize that introduction of AETCOM learning modules in the medical curriculum has a positive impact on students towards learning communication skills. Doctor-patient inter-relationship, treatment decision-making, etc., are dependent on doctor’s communication skills; which can be improved and strengthened with AETCOM implementation in medical curriculum.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A COMPARATIVE STUDY ON THE EFFECT OF GENERAL ANAESTHESIA ON BLOOD GLUCOSE LEVELS IN NON-DIABETIC AND CONTROLLED DIABETIC PATIENTS: AN OBSERVATIONAL STUDY AT S. M. S. MEDICAL COLLEGE, JAIPUR 关于全身麻醉对非糖尿病患者和受控糖尿病患者血糖水平影响的比较研究:杰浦尔 S. M. S. 医学院的观察研究
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4013
Rajeev Sharma, Ajay Singh, Sandeep Chhipa
{"title":"A COMPARATIVE STUDY ON THE EFFECT OF GENERAL ANAESTHESIA ON BLOOD GLUCOSE LEVELS IN NON-DIABETIC AND CONTROLLED DIABETIC PATIENTS: AN OBSERVATIONAL STUDY AT S. M. S. MEDICAL COLLEGE, JAIPUR","authors":"Rajeev Sharma, Ajay Singh, Sandeep Chhipa","doi":"10.22159/ijcpr.2024v16i1.4013","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4013","url":null,"abstract":"Objective: Diabetes, a complex metabolic disorder, poses significant challenges during surgery due to its association with chronic hyperglycemia. Surgical stress triggers hormonal changes, impacting glucose homeostasis. With an increasing global prevalence of diabetes, understanding the interplay between surgery, stress, and diabetes becomes crucial for perioperative management. \u0000Methods: This hospital-based cross-sectional observational study included 222 patients (111 non-diabetic and 111 controlled diabetic) undergoing elective surgery. Demographic data, hemodynamic parameters, and blood glucose levels were assessed at various intervals. Statistical analyses compared age, gender, blood glucose levels, and hemodynamic responses between the two groups. \u0000Results: Demographic parameters were comparable between non-diabetic and controlled diabetic groups. Hemodynamic responses, including heart rate and blood pressure, showed no significant differences during the surgery. Blood glucose levels were similar preoperatively and up to 30 min post-intubation. However, a significant difference was observed after 5 min of extubation, with controlled diabetic patients exhibiting higher levels. Variations in blood glucose levels after extubation were statistically significant, emphasizing the importance of postoperative monitoring. \u0000Conclusion: This study highlights the intricate relationship between surgery, stress, and diabetes, emphasizing the need for tailored perioperative management. Close monitoring, especially during critical moments, is essential to ensure optimal glucose control and mitigate complications. The findings align with existing literature, reinforcing the importance of individualized approaches for diabetic patients undergoing surgery.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139530051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A COMPARISON OF INTRAPERITONEAL INSTILLATION OF ROPIVACAINE AND ROPIVACAINE WITH DEXMEDETOMIDINE FOR POSTOPERATIVE ANALGESIA FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY: A PROSPECTIVE STUDY 腹腔镜胆囊切除术后腹腔内灌注罗哌卡因和罗哌卡因加右美托咪定进行术后镇痛的比较:一项前瞻性研究
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4011
Priyanka Sharma, Priyanka Saini, MEGHA SHARMA, Manish Khandelwal
{"title":"A COMPARISON OF INTRAPERITONEAL INSTILLATION OF ROPIVACAINE AND ROPIVACAINE WITH DEXMEDETOMIDINE FOR POSTOPERATIVE ANALGESIA FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY: A PROSPECTIVE STUDY","authors":"Priyanka Sharma, Priyanka Saini, MEGHA SHARMA, Manish Khandelwal","doi":"10.22159/ijcpr.2024v16i1.4011","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4011","url":null,"abstract":"Objective: laparoscopic cholecystectomy surgeries are having advantages over open cholecystectomy with less pain and quick recovery. Intraperitoneal route of administration of a local anaesthetic is a cheap, easy and non-invasive method of reducing the intensity of post laparoscopic pain. This study compared the postoperative analgesic effect of intraperitoneal instillation of ropivacaine 0.5% and ropivacaine 0.5% with dexmedetomidine (1µg/kg) in patients undergoing laparoscopic cholecystectomy under general anaesthesia. \u0000Methods: Total 86 patients were divided equally in 2 groups. Patients in group R received 20 ml 0.5% isobaric ropivacaine hydrochloride+5 ml NS where in Group RD, patients received 20 ml 0.5% isobaric ropivacaine hydrochloride with 1µg/kg dexmedetomidine hydrochloride. Solution was diluted with normal saline to make a total volume 25 ml. Hemodynamic parameters were noted during surgery Postoperatively, patient was assessed for pain using the visual analogue scale (VAS) at 30 min, then 2,4,8,12 and 24 h. Total analgesic consumption in the first 24 h also compared. \u0000Results: Baseline demographic profile of study participants were similar. Mean duration of analgesia was significantly higher in group RD (10.05±6.916 h) as compared to group R (5.59±6.8) (p=0.003). Mean dose of rescue analgesia was significantly higher in group R (130.81±61.44) as compared to group RD (75±36.6) (p<0.001). VAS score was significantly higher in group R as compared to group RD at different time intervals. \u0000Conclusion: We concluded that intraperitoneal Ropivacaine with Dexmedetomidine produced postoperative analgesia better than ropivacaine alone.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UNLOCKING THE FUTURE OF MATERNAL HEALTH: PLATELET INDICES AS PREDICTORS OF PREECLAMPSIA 开启孕产妇健康的未来:预测子痫前期的血小板指数
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4008
Praveen Singh, Pooja Arnote, Kajal Thakur
{"title":"UNLOCKING THE FUTURE OF MATERNAL HEALTH: PLATELET INDICES AS PREDICTORS OF PREECLAMPSIA","authors":"Praveen Singh, Pooja Arnote, Kajal Thakur","doi":"10.22159/ijcpr.2024v16i1.4008","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4008","url":null,"abstract":"Objective: Preeclampsia is a dangerous pregnancy condition that puts the health of the mother and fetus at great risk. Early diagnosis and treatment of this illness depend on predictive signs. Because of their correlation with coagulation problems, platelet indices, such as platelet count (PC), platelet distribution width (PDW), mean platelet volume (MPV), and platelet crit (PCT), may be useful as biomarkers for preeclampsia. The purpose of this study is to find out how well platelet indices can predict preeclampsia. \u0000Methods: From Mar 1, 2021, to Feb 28, 2022, the study was carried out at the Kamla Nehru State Hospital for Mother and Child in Shimla, Himachal Pradesh. Pregnant women without pre-existing illnesses were removed, and those with normotension who had singleton pregnancies after 20 w of gestation were included. Patients were classified according to the degree and course of preeclampsia, and platelet indices were monitored during pregnancy. To ascertain the significance of fluctuations in the platelet index, statistical tests were conducted and data were analyzed using SPSS-PC-25. \u0000Results: According to the study, patients with preeclampsia (PE) and normotensive individuals had significantly different platelet indices. Compared to people with normotension, PE patients showed higher platelet distribution width (PDW), a lower platelet count, and an elevated mean platelet volume (MPV). Interestingly, MPV increased noticeably in PE before blood pressure rose. In severe PE patients, the platelet count drastically reduced. The potential of MPV and platelet count as predictors of PE was shown by Receiver Operating Characteristic (ROC) curve analysis. These results demonstrate the importance of platelet indices in the diagnosis of PE and the potential use of these indices as early indicators of this hypertensive condition in pregnancy. \u0000Conclusion: Platelet indices show potential as early indicators for identifying and tracking preeclampsia, especially platelet count, MPV, and PDW. Monitoring platelet indices in addition to blood pressure may help determine the extent and course of the illness, which might lead to better results for both the mother and the fetus. To improve clinical usefulness and improve prediction models, more research in this area is necessary.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CLINICO-EPIDEMIOLOGICAL PROFILE AND HOSPITAL OUTCOMES OF COVID-19 PATIENTS DURING ALL THREE WAVES, AN EXPERIENCE FROM A RURAL TERTIARY CARE CENTER, EASTERN UTTAR PRADESH, INDIA 印度东部乌塔尔邦一个农村三级医疗中心的经验:Covid-19 患者在所有三个波次中的临床流行病学概况和住院治疗结果
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4014
Surabhi Shukla, Naveen Goyal, Priyanka Rai, Swaraj Sharma, V. Maurya, Vikas Kumar Gupta
{"title":"CLINICO-EPIDEMIOLOGICAL PROFILE AND HOSPITAL OUTCOMES OF COVID-19 PATIENTS DURING ALL THREE WAVES, AN EXPERIENCE FROM A RURAL TERTIARY CARE CENTER, EASTERN UTTAR PRADESH, INDIA","authors":"Surabhi Shukla, Naveen Goyal, Priyanka Rai, Swaraj Sharma, V. Maurya, Vikas Kumar Gupta","doi":"10.22159/ijcpr.2024v16i1.4014","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4014","url":null,"abstract":"Objective: In this study, an attempt has been made to report the clinical profile, exposure characteristics and outcomes of the COVID-19 patients admitted to our rural tertiary care facility. \u0000Methods: It is a single-centric retrospective observational study and includes data from January 2020 to March 2022. The data were retrieved from patient files. We have recorded patient demography, clinical and laboratory parameters and outcome of the patients. Patients were categorized based on disease severity according to WHO guidelines. Appropriate statistical analysis was applied and p value<0.05 was considered as significant. \u0000Results: A total of 2339 patients were included in this study. Total males were 67%, mean age group was 45.43±18.48 y (0 to 101 y), with majority belonging to 46-60 y age group (27.2%). Total comorbid patients were 29.3% with 9.4% accounting for more than one comorbidities. Most common comorbidity noted was diabetes mellitus 15.8% followed by hypertension 13.4%. Total mortality was noted to be 16.2%. Fever was the most common symptom (92%) followed by cough (51%) and myalgia (30%). Disease severity and outcome was significantly correlated with advancing age and the presence of underlying comorbidities. \u0000Conclusion: Rural population had comparable proportion of comorbidities as well as mortality. Common risk factors for severe disease in rural setting were similar to urban setting and old age and more than one comorbidities. Country-wide rural data should be collected for a better understanding of COVID-19 disease in rural and remote population.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
REVOLUTIONIZING PHARMACEUTICALS: A DEEP DIVE INTO SELF NANO EMULSIFYING DRUG DELIVERY SYSTEMS 彻底改变制药业:深入研究自纳米乳化给药系统
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4019
Prajwal Nikam, Aparna Jain, Dipti Solanki, Shubhangi Aher
{"title":"REVOLUTIONIZING PHARMACEUTICALS: A DEEP DIVE INTO SELF NANO EMULSIFYING DRUG DELIVERY SYSTEMS","authors":"Prajwal Nikam, Aparna Jain, Dipti Solanki, Shubhangi Aher","doi":"10.22159/ijcpr.2024v16i1.4019","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4019","url":null,"abstract":"From nearly a decade’s time, there has been an increased inclination with respect to nanoemulsions owing to their augmented and ameliorated characteristics in comparison to conventional methods of drug delivery. Self-nano-emulsifying drug delivery systems (SNEDDS) have substantiated their effectiveness in enhancing the solubility and bioavailability of poorly soluble substances. These systems, often isotropic mixtures, consist of oils, surfactants, and cosurfactants/cosolvents. They possess the capability to create nanoemulsions or fine oil-in-water (o/w) emulsions with mild stirring and dilution by the water phase along the gastrointestinal tract. This system has proven its worth in enhancing the absorption of lipophilic agents constrained by dissolution rate. SNEDDS are extremely efficacious in improving the oral bioavailability of lipophilic products and is quite promising for managing drugs unapt for oral delivery. Additionally, it's noteworthy that SNEDDS can be formulated into various solid dosage forms suitable for both oral and parenteral administration. This overview incorporates the advancements of SNEDDS' the mechanism involved in its spontaneous formation, its subcategories, composition, approaches employed for formulation, characterization, merits and limitations, and future potential. The review also lays stress on the progress in solid self-emulsifying delivery mechanisms and dosage forms.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139621551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A SYSTEMATIC REVIEW ON NANO DRUG DELIVERY SYSTEM: SOLID LIPID NANOPARTICLES (SLN) 纳米给药系统:固体脂质纳米颗粒(SLN)系统综述
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4020
Swapnil D. Phalak, Vishal Bodke, Reenu Yadav, Satish Pandav, Maloji Ranaware
{"title":"A SYSTEMATIC REVIEW ON NANO DRUG DELIVERY SYSTEM: SOLID LIPID NANOPARTICLES (SLN)","authors":"Swapnil D. Phalak, Vishal Bodke, Reenu Yadav, Satish Pandav, Maloji Ranaware","doi":"10.22159/ijcpr.2024v16i1.4020","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4020","url":null,"abstract":"Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tiny materials are used as diagnostic tools or to deliver therapeutic drugs to specific targeted locations in a controlled manner. Nanotechnology has numerous advantages in the treatment of chronic human diseases through the site-specific and target-oriented delivery of precise medications. There have recently been several notable applications of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, and so on) in the treatment of various disorders. Efficient use of pricey medications and excipients, as well as cost savings in manufacturing Beneficial to patients, improved therapy, comfort, and the standard of living. Lipids have been proposed as an alternate carrier to circumvent the constraints of polymeric nanoparticles, notably for lipophilic medicines. Such small particles of lipid are known as solid lipid nanoparticles (SLNs), and they are gaining popularity among formulators all over the world. SLNs are colloidal carriers that were developed in the last decade as a replacement for traditional carriers. Lipid nanoparticles have caught the interest of researchers during the last two decades and have shown considerable therapeutic success since the first clinical approval of Doxil in 1995. Simultaneously, lipid nanoparticles have shown significant promise in conveying nucleic acid medications, as proven by the approval of two RNA treatments and an mRNA COVID-19 vaccination.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139620451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPROVING EFFICIENCY IN PRE-ECLAMPSIA DIAGNOSIS: SPOT URINARY PROTEIN/CREATININE RATIO 提高子痫前期诊断的效率:定点尿蛋白/肌酐比值
International Journal of Current Pharmaceutical Research Pub Date : 2024-01-15 DOI: 10.22159/ijcpr.2024v16i1.4007
PRAVEEN SINGH, Pooja Arnote, Kajal Thakur
{"title":"IMPROVING EFFICIENCY IN PRE-ECLAMPSIA DIAGNOSIS: SPOT URINARY PROTEIN/CREATININE RATIO","authors":"PRAVEEN SINGH, Pooja Arnote, Kajal Thakur","doi":"10.22159/ijcpr.2024v16i1.4007","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i1.4007","url":null,"abstract":"Objective: Because pre-eclampsia can cause difficulties, it presents a serious threat to maternal healthcare. The well-being of both the mother and the fetus depends on a prompt and precise diagnosis. There are drawbacks to using conventional techniques, such as collecting urine for a whole day to determine proteinuria. Although the spot urine protein/creatinine ratio is a faster option, its clinical value is yet unknown. \u0000Methods: The purpose of this cross-sectional study, which ran from July 1, 2018, to June 30, 2019, was to evaluate the spot urine protein/creatinine ratio in preeclamptic pregnant women vs the traditional 24 h urine protein collection technique. Ninety inpatients in all who satisfied certain inclusion and exclusion criteria were included. \u0000Results: Compared to comparable research by Hanumant et al. (13%), 6.66% of patients in our study had abnormal fundus examination findings. Papilloedema was absent from all participants, and the cautious management of anomalies was consistent across investigations. In line with the results of Hossain et al. and Sapna et al., the mean urine protein creatinine ratio in our investigation was 1.75±2.32. A smaller ratio was discovered by Umran et al., whereas Jung Hwa Park et al. claimed a larger ratio. Jung Hwa Park et al. also showed a greater mean protein excretion during a 24 h period (2713±2003 mg/d). \u0000Conclusion: This research at Kamla Nehru Hospital emphasizes the spot urine protein/creatinine ratio's potential as an effective pre-eclampsia diagnostic tool. In healthcare settings with limited resources, prompt detection of severe proteinuria can improve maternal and fetal outcomes by streamlining patient treatment.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A SENSITIVE AND A SIMPLE RP-HPLC METHOD DEVELOPMENT AND VERIFICATION FOR THE QUANTITATIVE ESTIMATION OF CHOLECALCIFEROLIN TABLETS 建立并验证灵敏简便的 RP-HPLC 方法定量测定胆囊收缩素片
International Journal of Current Pharmaceutical Research Pub Date : 2023-11-15 DOI: 10.22159/ijcpr.2023v15i6.3097
K. Subhashini, U. T. Naidu, A. A. Kumar, Rajesh Vooturi, N. Kumar
{"title":"A SENSITIVE AND A SIMPLE RP-HPLC METHOD DEVELOPMENT AND VERIFICATION FOR THE QUANTITATIVE ESTIMATION OF CHOLECALCIFEROLIN TABLETS","authors":"K. Subhashini, U. T. Naidu, A. A. Kumar, Rajesh Vooturi, N. Kumar","doi":"10.22159/ijcpr.2023v15i6.3097","DOIUrl":"https://doi.org/10.22159/ijcpr.2023v15i6.3097","url":null,"abstract":"Objective: To develop a sensitive, simple, accurate, precise and linear Reverse Phase High-Performance Liquid Chromatographic (RP-HPLC) method and verify for the quantitative estimation (Assay) of Cholecalciferol in tablets. Methods: The optimized method uses a reverse phase column, Waters X-Bridge C8 (150 X 4.6 mm; 3.5μ), a mobile phase of Methanol: Acetonitrile: HPLC grade water/Milli-Q water in the proportion of 60:30:10 v/v/v, flow rate of 0.8 ml/min, injection volume of 100 µl, and detection wavelength of 265 nm using a UV/PDA detector. Results: The developed method gave Cholecalciferol eluting at about 9 min. Cholecalciferol exhibited linearity in the range 0.058-0.466 μg/ml. The precision is exemplified by a relative standard deviation of 1.40%. Percentage of individual recovery was found to be in the range of 97.0 and 103.0 during accuracy studies. Conclusion: A sensitive, simple, accurate, precise and linear RP-HPLC method was developed and verified for the quantitative estimation (Assay) of Cholecalciferol in tablets and hence this method can be explored for the analysis of Cholecalciferol in tablets/various dosage forms in various pharmaceutical industries.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139271371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INTRA-OPERATIVE MAGNESIUM SULPHATE INFUSION DECREASES AGITATION AND PAIN IN PATIENTS UNDERGOING FUNCTIONAL ENDOSCOPIC SINUS SURGERY-A PROSPECTIVE, RANDOMIZED, CONTROLLED AND DOUBLE-BLINDED CLINICAL TRIAL 术中输注硫酸镁可减少功能性内窥镜鼻窦手术患者的躁动和疼痛--一项前瞻性、随机、对照和双盲临床试验
International Journal of Current Pharmaceutical Research Pub Date : 2023-11-15 DOI: 10.22159/ijcpr.2023v15i6.3087
Aman Sai Guntreddy, Korra Gopa Naik, Behara Girish
{"title":"INTRA-OPERATIVE MAGNESIUM SULPHATE INFUSION DECREASES AGITATION AND PAIN IN PATIENTS UNDERGOING FUNCTIONAL ENDOSCOPIC SINUS SURGERY-A PROSPECTIVE, RANDOMIZED, CONTROLLED AND DOUBLE-BLINDED CLINICAL TRIAL","authors":"Aman Sai Guntreddy, Korra Gopa Naik, Behara Girish","doi":"10.22159/ijcpr.2023v15i6.3087","DOIUrl":"https://doi.org/10.22159/ijcpr.2023v15i6.3087","url":null,"abstract":"Objective: To assess the potential role of magnesium sulphate in the reduction of postoperative agitation and pain following functional endoscopic sinus surgery d in the ENT department. Methods: A prospective, randomized controlled double blinded clinical trial was carried out on 100 patients belonging to both sexes, aged between 18-55 y, posted for functional endoscopic sinus surgery (FESS) under general anaesthesia. Results: Intraoperative administration of magnesium sulphate in patients undergoing functional endoscopic sinus surgery decreases postoperative agitation and pain intensity; rescue analgesic consumption in the early postoperative period; and the length of stay in PACU. Conclusion: Intravenous Magnesium sulfate decreases patient agitation and pain after functional endoscopic sinus surgery.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139272577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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