Iranian Journal of Pediatric Hematology & Oncology最新文献

{"title":"Volume, Conductivity and Scatter parameters of Neutrophils in Neonatal Sepsis – Is it a Cost-Effective Tool?","authors":"N. Ganesan, Anupama Mohan, Ramesh Srinivasan, T.M. Subba Rao","doi":"10.18502/ijpho.v12i3.10060","DOIUrl":"https://doi.org/10.18502/ijpho.v12i3.10060","url":null,"abstract":"Background: Early diagnosis of neonatal sepsis is quite challenging. I/T ratio (immature to mature neutrophil ratio) is a highly sensitive marker of sepsis but is time-consuming and subjective. Off late, volume conductivity and scatter (VCS) of neutrophils are among the newer parameters available for screening a septic neonate. This study aimed to determine the correlation between the I/T ratio and VCS parameters in neonatal sepsis and estimate a cut-off value of VCS parameters to diagnose neonatal sepsis using receiver operating curve analysis. \u0000Materials and Methods: This prospective observational study was conducted by the Department of Pathology and Neonatology from April 2019 to March 2020 in a tertiary care center. A total of 110 newborns were included in this study and were divided into two groups (probable sepsis and sepsis). Data were collected from the hospital database, and analysis was done using SPSS software. Correlation between the I/T ratio and VCS parameters was done using Spearman’s correlation. Results were expressed as mean ± standard deviation (SD). A P-value of <0.05 was considered statistically significant.  \u0000Results: Correlation between the I /T ratio and VCS parameters showed negative correlation values of -0.22, -0.23, and +0.39 (P-values of 0.0198, 0.0153, and <0.0001) for mean neutrophil conductivity (MNC), mean neutrophil scatter (MNS) and mean neutrophil volume (MNV) respectively. MNV with a cut-off of > 156.4 had sensitivity and a negative predictive value of 100 % in the diagnosis of sepsis and was found to be higher in the sepsis group when compared to the probable sepsis group. \u0000Conclusion: Based on the significant difference in VCS parameters of neutrophils in the sepsis group, this aids as an additional marker for the early diagnosis of neonatal sepsis.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130025188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cytokine and its relation to depression and infection complications in pediatric cancer","authors":"Moslem Pourakrami, E. Sheikhpour, S. Mehrabani","doi":"10.18502/ijpho.v12i3.10063","DOIUrl":"https://doi.org/10.18502/ijpho.v12i3.10063","url":null,"abstract":"Inflammation plays a critical role in the progression of cancer in children. On the other hand, children with cancer experience abnormal activation of the inflammatory system. Moreover, it is known that these patients have a predisposition to depression. According to studies, moderate to severe depression was observed in about 63% of children with cancer and acute illness. Therefore, identifying inflammation-related biomarkers and targets in this regard is essential. The inflammation changes are related to cytokine deregulation, which in turn may influence the expression of depressive symptoms. Studies have reported that the deregulation of serum inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α may influence depressive disorder in pediatric cancer patients.  In addition, determining the risk of severe bacterial infection complications in pediatric cancer is essential to reduce the cost of therapy and hospitalization. However, the role of cytokines as an infection marker in these children is still a debate. Determining these plasma cytokine levels may have diagnostic value in assessing febrile neutropenia, although their crucial role in systemic inflammation is known. Given that evidence regarding the role of pro-inflammatory cytokine levels and relation to clinical parameters, including depression and infection in pediatric cancer patients is limited, we assessed the role of cytokine and its relation to depression and infection complications in pediatric cancer.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132961123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Ganoderic Acid A on miR-17-5p and miR-181b expression level and apoptosis induction in human leukemia Nalm-6 cells","authors":"Faezeh Mortazavie, Simin Taheri, Parisa Tandel, F. Zare, Gholmhossein Tamaddon","doi":"10.18502/ijpho.v12i3.10058","DOIUrl":"https://doi.org/10.18502/ijpho.v12i3.10058","url":null,"abstract":"Background: In various cancers, Ganoderic Acid A (GAA), an active triterpenoid derived from Ganoderma lucidum, has been proved to show potent anti-tumor effects. However, the possible impacts of GAA on the human leukemia cell line (Nalm-6) are not fully elucidated. Therefore, this research aimed to study the antineoplastic effect of GAA on Nalm-6 cells. \u0000Materials and Methods: In this laboratory trial study, Nalm6 cells were cultured in vitro and treated with different doses of GAA (25, 50, 100, 200, and 400 μg/mL) for 24, 48, and 72 hours. The optimal treatment concentration of GAA was determined by the MTT assay. Flow cytometry was used to determine the death of Nalm-6 cells caused by GAA treatment by utilizing FITC-conjugated propidium iodide (PI) and annexin V staining. After incubation, the expression levels of miR-17-5p and miR-181b were monitored using real-time polymerase chain reaction (PCR). \u0000Results: Based on the half-maximal inhibitory concentration (IC50) measurements of the MTT assay, the optimal treatment concentration of GAA was 140 μg/mL (in a dose and time-dependent manner, p<0.0001). The GAA treatment was selectively toxic to the leukemia Nalm-6 cells and could remarkably induce cell apoptosis (p<0.0001). Besides, GAA downregulated the expression of miR-17-5p and miR-181b in the Nalm-6 cells compared with the untreated cells (P=0.0067 and P=0.0014, respectively). \u0000Conclusions: Based on the present findings, GAA merits further investigation as a promising natural reagent for treating hematologic malignancies.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127930440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of two different doses of Filgrastim in febrile neutropenia management in childhood malignancy: A randomized clinical trial","authors":"N. Mirbehbahani, S. Bagheri, G. Roshandel, A. Jahazi, A. Rashidbaghan","doi":"10.18502/ijpho.v12i3.10057","DOIUrl":"https://doi.org/10.18502/ijpho.v12i3.10057","url":null,"abstract":"Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalized febrile neutropenic patients with cancer.  \u0000Materials and methods: In this randomized clinical trial, 60 febrile neutropenic patients with cancer complying with the inclusion criteria were assigned to both groups A and B. Thirty patients in group A received Filgrastim 5μg/kg/day whereas 30 others in group B received Filgrastim 15μg/kg/day. Hematological factors, physical examination findings, antibiotic administration period, and type of malignancy were then recorded. Complete blood count with differential (CBC diff) was also tested. Lung infiltration was examined by chest X-ray (CXR), and the spleen and abdomen were monitored by ultrasound. \u0000Results: The mean age of patients was 6 ± 3 years old. The most prevalent malignancies included acute lymphoblastic leukemia (ALL) (35.0%), neuroblastoma (18.3%), osteosarcoma (11.7%), acute myeloid leukemia (AML) (8.3%), and Rhabdomyosarcoma (8.3%). The frequency distribution of malignancies significantly differed between the two groups (P= .01). Changes in hematological factors, including white blood cells (WBC), mature neutrophil cells, and absolute neutrophil count (ANC) in group A, appeared lower than those in the other group. However, none of the studied factors, including hematological factors, physical examination findings, and antibiotic administration period, were found to differ significantly between the two groups (P> 0.05). \u0000Conclusion: Much as a higher dose of Filgrastim seems to bear a better effect on ANC, no significant difference was identified between the two groups. Further studies should be designed with a larger population to address the issue. ","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115575839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency Determination of c.1115_1118delTTGG and c.3788_3790delTCT FANCA Gene Mutation in North of Khyber Pakhtunkhwa (KPK) Pakistan Fanconi’s Anemia Population","authors":"Kinza Ayaz, Adnan Khan, Maria Arabdin, T. Masood, A. Taj, Maaz Ayaz","doi":"10.18502/ijpho.v12i3.10059","DOIUrl":"https://doi.org/10.18502/ijpho.v12i3.10059","url":null,"abstract":"Background: This study aimed to assess the frequency determination of c.1115_1118delTTGG and c.3788_3790delTCT Fanconi's anemia A gene (FANCA) gene mutation in the North of Khyber Pakhtunkhwa (KPK) Pakistan Fanconi’s Anemia Population. \u0000Materials and Methods: A cross-sectional study was conducted at Khyber Medical University, Peshawar, Pakistan. For the Exon 13 mutation c.1115_1118delTTGG, the amplification-refractory mutation system polymerase chain reaction (ARMS PCR) was developed. Sanger sequencing confirmed the ARMS PCR results for Exon 13 and found an exon 38 mutation of the FANCA (Fanconi anemia complementation group A) gene (c.3788_3790delTCT). Sanger sequencing results analyzed on Bio edit sequence aligner software confirmed the results of PCR. The four incidental single nucleotide polymorphisms (SNPs) discovered were examined in several variation databases. \u0000Results:  The mean age for the patients was 9.68±3.02 years, with an age range of 5–16 years. Pedigree analysis of Fanconi Anemia patients revealed an autosomal recessive pattern of inheritance. Physical characteristics such as skeletal abnormalities, specifically thumb abnormalities and Fanconi's facies, are distinctive diagnostic features of FA. Pedigrees also showed bone marrow hypoplasia in 65% of patients and red cell aplasia in 6%. PCR results from all samples revealed tahat none of them had the Exon 13 mutation. In addition, none of the samples had the Exon 38 mutation. Four SNPs were found in the Sanger sequencing. Two of them were in the intron 12 region, one in each of Exons 13 and 38. \u0000Conclusion: Results show that mutations in Exon 13 and Exon 38 of the FANCA gene are uncommon in our Pakistani FA population. SNPs established in the Pakistani population of Khyber Pakhtunkhwa (KPK) province have not been reported before.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126685883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Sleep Habits and Related Factors in Childhood Cancer Survivors: A Cross‐Sectional Study","authors":"F. Soheilipour, M. Faranoush, Atefeh Ghanbari Jolfaei, R. Tafreshi, Fatemeh Kashaninasab","doi":"10.18502/ijpho.v12i2.9077","DOIUrl":"https://doi.org/10.18502/ijpho.v12i2.9077","url":null,"abstract":"Background: Sleep habits may play a role in the onset of sleep disorders. Several factors affect sleep habits. This study aimed to investigate sleep habits and related factors in childhood cancer survivors (CCS). \u0000Materials and Methods: This cross-sectional study was performed on 400 children (age range: 5-15 years) who recovered from cancer in Tehran, Iran, in 2020. A 35-item Children's Sleep Habits Questionnaire (CSHQ) was used to determine children’s sleep habits. Correlation coefficient test, independent t-test, and one-way analysis of variance (ANOVA) were used to determine the correlation between results. \u0000Results: Participants’ mean age was 10.45± 12.3 years (49% males vs. 51% females). The mean total score of the CSHQ was 58.53±7.8. There was a negative and significant relationship between age and the total score of CSHQ (P=0.009). Independent t-test showed that the subscales and the total score of the CSHQ were not significantly different between males and females (P=0.834). There was no significant relationship between the total score of the CSHQ and the duration after recovery (P=0.08). \u0000Conclusions:  The CCS are at higher risk of sleep disorders and the possibility of sleep disorders is higher in younger patients. Girls and boys who have survived cancer are equally prone to sleep disorders. There is a possibility of developing sleep disorders at any time during the recovery period. Factors such as the family’s socioeconomic status, level of physical health, duration of cancer, and the age of the children should be considered when assessing and treating sleep problems in CCS.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131251383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe main bronchus obstruction due to pulmonary schwannoma: A Case Report","authors":"Ahmad Shirinzadeh, R. Ershadi, A. Amouei, J. Jafari, H. Soltani, S. Kargar, F. Binesh","doi":"10.18502/ijpho.v12i2.9079","DOIUrl":"https://doi.org/10.18502/ijpho.v12i2.9079","url":null,"abstract":"Pulmonary schwannoma is a rare neoplasm that arises from peripheral nerve sheath, Schwann cells, in the lungs and mostly remains asymptomatic for months. This report presents a seven-year-old female patient with an occasional cough and fever. She was hospitalized due to the lack of response to outpatient treatments, including antibiotics and antifebrile. A biopsy was taken from the mass by bronchoscopy, and the pathology report indicated the presence of a low-grade spindle cell, Verocay body, and Antoni B areas. Based on the pathologic findings, immunohistochemical (IHC) analysis was requested. The results indicated diffusely positive for S-100 protein, and accordingly, the diagnosis of schwannoma was confirmed. Thoracotomy and lobectomy were performed. Tracheobronchial schwannoma can be treated with surgical resection or bronchoscopy.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128182553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cutoff of ferritin for evaluation of osteoporosis in patients with Thalassemia Major: A cross-sectional analytic study","authors":"A. Baghersalimi, B. Darbandi, Azadeh Sadeghivash, Shahin Koohmanaee, A. Hassanzadeh Rad, Hossein Firouzi, Setila Dalili","doi":"10.18502/ijpho.v12i2.9076","DOIUrl":"https://doi.org/10.18502/ijpho.v12i2.9076","url":null,"abstract":"Background: This study aimed to assess cutoff of ferritin for evaluation of osteoporosis in patients with Thalassemia Major (TM). \u0000Materials and Methods: This analytic cross-sectional study was conducted in17 Shahrivar children's hospital, Rasht, Iran, from November 2017 to November 2018. The inclusion criteria were indicated as the presence of  TM in patients aged 12-19 years old with records of their regular visits. The exclusion criteria were noted as the presence of any chronic bone diseases such as osteomalacia or osteogenesis imperfecta, delayed puberty, hypothyroidism, parathyroid dysfunction, renal failure, liver failure, and growth hormone deficiency. Ferritin level was assessed, and bone densitometry was performed for all patients with TM. \u0000Results: In this study, 53 females (54.6%) and 44 males (43.4%) were enrolled. Results showed that 36 (37.1%), 49 (50.5%), and 12 (12.4%) patients had a normal bone density, osteopenia, and osteoporosis, respectively. Comparing these three groups showed that despite higher mean serum level of ferritin in TM patients with osteoporosis than patients with osteopenia and normal bone density, no significant statistical difference was noted in these three groups (P >0.05). Besides, the mean ferritin level in patients with abnormal bone densitometry (osteopenia and osteoporosis) was higher than in patients with normal ones. A significant difference was noted between abnormal and normal densitometries (p=0.03). The Area under the Curve for ferritin was 0.708, and the cutoff point was indicated for ferritin was 2006 ng/ml. \u0000Conclusion:  Regarding the results, there was a high frequency of osteoporosis and osteopenia in teenagers with TM. As bone density abnormality formation is time-consuming, and prevention is the primary strategy for management, it is highly recommended to assess bone mineral density regularly starting from early childhood.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126543897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology of Childhood Lymphadenopathy: A Report by a Single-center (2016-2018)","authors":"H. Raji, Roohollah Edalatkhah, B. Ashjaei, Seifollah Mohseni","doi":"10.18502/ijpho.v12i2.9073","DOIUrl":"https://doi.org/10.18502/ijpho.v12i2.9073","url":null,"abstract":"Background: Lymphadenopathy is an enlargement of a lymph node. Pathologic Lymphadenopathy is when there is a symptom of infectious and noninfectious abnormalities or malignant diseases. Most Lymphadenopathies are benign and are associated with a short period of symptoms. Concerning diagnosis and management of adenopathy, especially in the case of children, research is still underway. For this reason, our study investigated and analyzed the causes of lymphadenopathy in children. \u0000Materials and Methods: This is a retrospective study conducted at the Pediatric Department of children's medical center of Tehran University of medical science. In this study, 130 children with cervical lymphadenopathy aged under 12 years underwent lymph node biopsy. Then under general anesthesia and evaluation of a senior pathologist, the lymph node was excised and biopsied. \u0000Results: During the study, twenty-five cases were excluded. Fifty-three patients (50.47%) demonstrated infection history, 22 cases (21%) had neoplasia, and reactive inflammatory changes with nonspecific origin were seen in 42 cases (40.0%). We observed chronic lymphadenitis in 3(2.9%) cases, and finally, 1(1.0%) case was metastatic. Mean lymph node size proved to be greater than two cm in metastatic (2.22cm), lymphoma (2.33cm), and granulomatous (3.17cm) lymphadenopathies. The average lymph node size turned out to be 1.53 cm in reactive lymph nodes (P =0.021). The diagnosis was obtained by excisional biopsy and histopathology. \u0000Conclusion: Acute infections are the most common reason for lymphadenopathy in pediatric conditions. It is better to be suspicious of malignancy with a high index in cases of cervical lymphadenopathy, especially if the lymph node size is higher than 2 cm. History, clinical features, and paraclinical tests can be used for lymphadenopathy in children.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"5 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130098751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Evaluation of Hematological Sepsis Score and Presepsin in Neonatal Sepsis","authors":"Marina Mamdouh Malky Ibrahim, Dalia Ahmed El-Sewefy, Mariam John Amin Ibrahim, Shaimaa Abdelmalik Pessar","doi":"10.18502/ijpho.v12i2.9075","DOIUrl":"https://doi.org/10.18502/ijpho.v12i2.9075","url":null,"abstract":"Background: Early detection of neonatal sepsis and categorization of patients based on clinical severity is not yet effectively achieved. Some hematological parameters are used to formulate a hematological scoring system (HSS) and a modified hematological scoring system (MHSS) to diagnose neonatal sepsis. A promising biomarker: Presepsin, or Soluble Cluster of Differentiation 14 SubType (sCD14-ST), is a proteolysis product of CD14 produced after immune activation during infections. The purpose of this research is to assess the performance of both hematological sepsis scores and serum presepsin level in neonatal sepsis and compare them to C-reactive protein (CRP) as diagnostic tools and predictors of mortality. \u0000Materials and Methods: This case-control study comprised two groups, one group comprised 51 neonates who were further subgrouped into suspected & proved sepsis, along with 30 uninfected neonates as the control group. Both groups were subjected to the calculation of HSS and MHSS, serum presepsin levels, CRP measurement, and blood culture and assessed for clinical severity and mortality. \u0000Results: Hematological sepsis scores and presepsin levels were significantly higher in the sepsis group (P <0.001). Presepsin showed the best diagnostic performance at > 0.5 ng/ml (AUC 0.979; sensitivity of 94.1% and specificity of 100%). While HSS and MHSS at a cutoff value > 1 achieved comparable specificity, lower sensitivity, 72.6% for the former and 76.5% for the later was noted. Presepsin also was significantly higher in the dead group (P<0.004) with the best predictive performance over CRP at cutoff value >1.9 ng/ml (AUC 0.838; sensitivity of 85.7% and specificity of 79.6%). \u0000Conclusion: Hematological sepsis scores and presepsin were useful diagnostic tools in neonatal sepsis, with presepsin as a good predictor of mortality comparable to CRP.","PeriodicalId":129489,"journal":{"name":"Iranian Journal of Pediatric Hematology &amp; Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129211387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}