Green Synthesis and Catalysis最新文献_第8页

Enantioselective domino alkyl arylation of vinyl phosphonates by combining photoredox and nickel catalysis 通过光氧化和镍催化相结合实现乙烯基膦酸盐的对映选择性多米诺烷基芳基化

Green Synthesis and Catalysis Pub Date : 2024-04-01 DOI: 10.1016/j.gresc.2024.04.001

Tingzhi Lin, Guorong Li, Qianqian Lu, Chen Zhang, Yanen Wang, Fei Xing, Yundong Xu, Kun Yang, Dan Xiong, Xiufang Xu, P. J. Walsh, Jianyou Mao

引用次数: 0

Palladium-catalyzed tandem aza-Heck reaction of alkene-tethered oxime esters with cyclopropanols 钯催化的烯系肟酯与环丙醇的串联杂氮-赫克反应

Green Synthesis and Catalysis Pub Date : 2024-04-01 DOI: 10.1016/j.gresc.2024.04.002

Kangning Cao, Shutao Qi, Jianhui Li, Wenshao Ye, Junfeng Yang, Junliang Zhang, Fener Chen

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N-Heterocyclic nitrenium-catalyzed photoreductive radical-polar crossover for alkene dicarbofunctionalization N-Heterocyclic nitrenium-catalyzed photoreductive radical-polar crosssover for alkene dicarbofunctionalization（N-杂环腈催化光导自由基-极性交叉用于烯烃的二羧基官能化

Green Synthesis and Catalysis Pub Date : 2024-03-18 DOI: 10.1016/j.gresc.2024.03.002

Youfeng Han, Beibei Zhang, Zhixiang Wang, Xiangyu Chen

引用次数: 0

Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients 转氨酶催化的活性药物成分不对称合成

Green Synthesis and Catalysis Pub Date : 2024-03-16 DOI: 10.1016/j.gresc.2024.03.003

Yiman Cui, Yadong Gao, Licheng Yang

{"title":"Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients","authors":"Yiman Cui, Yadong Gao, Licheng Yang","doi":"10.1016/j.gresc.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.gresc.2024.03.003","url":null,"abstract":"Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts, have emerged as green, efficient, and highly selective solutions for substrates containing ketones or aldehydes, demonstrating exceptional performance in the synthesis of active drug molecules and natural products. This review primarily centers on the application of transaminases in the synthesis of important drug molecules bearing chiral amine group on acyclic or cyclic backbones. We delve into specific examples, highlighting the catalytic prowess of the sole transaminase catalyst as well as the combination with other enzymes in cascade transformations. This review illustrates the primary challenges that transaminases face and provides practical solutions that have been developed in these contexts. These solutions encompass various strategies and techniques that enhance the applicability and efficiency of transaminase-catalyzed reactions. In closing, we offer an outlook on the future of transaminase applications, discussing potential developments and emerging areas where this green and selective catalysis may play a pivotal role.","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140148130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling chemical glycosylation: DFT insights into factors imparting stereoselectivity 揭开化学糖基化的神秘面纱：通过 DFT 深入了解赋予立体选择性的因素

Green Synthesis and Catalysis Pub Date : 2024-03-15 DOI: 10.1016/j.gresc.2024.03.004

Aoxin Guo, Yuan Xu, Zhenhua Jia, Teck-Peng Loh, Xue-Wei Liu

{"title":"Unraveling chemical glycosylation: DFT insights into factors imparting stereoselectivity","authors":"Aoxin Guo, Yuan Xu, Zhenhua Jia, Teck-Peng Loh, Xue-Wei Liu","doi":"10.1016/j.gresc.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.gresc.2024.03.004","url":null,"abstract":"Stereoselective chemical glycosylation reactions are pivotal for preparing manifold biologically and medically important compounds, while mechanisms of chemical glycosylation reactions remain obscure and largely speculative. Herein, we performed DFT calculations to delve into the multifaceted mechanistic details of glycosylation reactions, including the equilibria among reactive glycosyl triflate intermediates in solution, the stereoselectivity imparting protecting groups, solvent effects, base, and the anomeric effect. Our results provided theoretical corroborations to 2-OAc neighbouring group participation (NGP), the arming/disarming effect, the coordination theory of solvent effect on glycosylation stereochemistry, and the influence of solvent polarity on the reaction kinetics spanning the S1-S2 continuum. For the first time, the existence of putative contact-ion-pairs (CIP) of glycosyl oxocarbenium and triflate anion in organic solutions was theoretically confirmed with the identification of multiple ground state structures employing an implicit Solvation Model based on Density (SMD). Kinetics of nucleophilic attack of model glucosyl triflates by simple alcohol acceptors ethanol (EtOH) and trifluoroethanol (TFE), complexed with 2,4,6-tri--butylpyrimidine (TTBP) were explored, revealing the essential role of the close accompanying base for rendering glycosidic bond formation thermodynamically favorable. Our work deepens the comprehension of the glycosylation mechanism, paving the way for the rational design and future advancement of efficient and environmentally friendly stereoselective glycosylation reactions.","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140148065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo- and electro-induced perfluoroalkylation/cyclization of o-hydroxyaryl enaminones: Synthesis of perfluoroalkyl chromones 邻羟基芳基烯酮的光诱导和电诱导全氟烷基化/环化：全氟烷基色酮的合成

Green Synthesis and Catalysis Pub Date : 2024-03-13 DOI: 10.1016/j.gresc.2024.03.001

Shengjie Song, Wenjian Wang, Jun Sun, Can Luo, Chunlei Wu, Jianjun Li

引用次数: 0

Enantioselective synthesis of planar chiral ferrocenes via gold(I)-catalyzed hydroarylation of N-ferrocenyl propiolamides 通过金(I)催化的 N-二茂铁基丙炔酰胺的加氢反应对平面手性二茂铁进行对映选择性合成

Green Synthesis and Catalysis Pub Date : 2024-03-08 DOI: 10.1016/j.gresc.2024.02.007

Qian Zhou, Lulin Qiao, An-An Zhang, Lu Li, Tuan-Jie Meng, Baomin Fan, Yuan-Yuan Gao, Lantao Liu

引用次数: 0

Mild and green thioacylation with dithiocarboxylates via photoredox catalysis 通过光氧化催化与二硫代羧酸进行温和绿色的硫代酰化反应

Green Synthesis and Catalysis Pub Date : 2024-03-07 DOI: 10.1016/j.gresc.2024.02.008

Wen-Chao Gao, Wei Li, Juan Zhang, Hong-Hong Chang, Rong Zhou

引用次数: 0

Palladium-catalyzed halosulfonylation of alkynes with ionic liquid as the green solvent and halide sources 以离子液体为绿色溶剂和卤化物源的钯催化炔烃卤磺化反应

Green Synthesis and Catalysis Pub Date : 2024-02-26 DOI: 10.1016/j.gresc.2024.02.003

Yin-Long Lai, Li-Yun Wu, Xun Xiong, Yi-Wei Lan, Yin-Yun Lin, Rui-Min Zhong, Huanfeng Jiang, Jianxiao Li

引用次数: 0

1,5-Pentanediol production from 3,4-dihydro-2H-pyran and acetic acid via successive reactions of esterification and hydrogenation 通过酯化和氢化连续反应从 3,4-二氢-2H-吡喃和乙酸中生产 1,5-戊二醇

Green Synthesis and Catalysis Pub Date : 2024-02-24 DOI: 10.1016/j.gresc.2024.02.005

Siyuan Zhao, Hong Du, Qi Fang, Yuying Li, Lei Wu, Xiumei Liu, Feng Wang

引用次数: 0