Turkish Journal of Clinics and Laboratory最新文献

{"title":"Efficacy of Intravenous Ibuprofen and Acetaminophen on Postoperative Pain and Tramadol Consumption in Laparoscopic Cholecystectomy: Prospective, Randomized, Double-blinded Clinical Trial","authors":"Z. Ersoy, C. Araz","doi":"10.18663/tjcl.1260384","DOIUrl":"https://doi.org/10.18663/tjcl.1260384","url":null,"abstract":"Background: Many techniques, including multimodal analgesia, have been used to manage postoperative pain after laparoscopic cholecystectomy (LC). Although the number of studies using intravenous ibuprofen (IV) is still limited, ibuprofen has been shown to have a potential role in managing postoperative pain. The primary outcome of this study is to evaluate and compare the impact of IV forms of ibuprofen and acetaminophen on 24-hour postoperative opioid consumption and pain management in patients undergoing LC. The second outcome of the study is to evaluate the impact of ibuprofen and acetaminophen on opioid-related adverse events (ORAE). \u0000Materials and Methods: This study was a prospective, randomized, double-blind clinical trial. Following ethical committee approval, 70 patients aged 18 to 65, American Society of Anesthesiology (ASA) score I- II, and those scheduled for LC were enrolled in the study. Patients were randomly divided into two groups. The control group (n=35) received 800 mg IV ibuprofen (group I) in 100 mL saline during surgery, while the acetaminophen group (n=35) received 1000 mg (group A). In the postoperative period, all patients received a patient-controlled analgesia (PCA) device with tramadol. The PCA device was set to a bolus dose of 10 mg and had a lockout time of 15 minutes. A blinded pain nurse assessed postoperative analgesia at 1, 2, 4, 6, 12, and 24 hours using a numerical rating scale (NRS). The incidence of postoperative nausea and vomiting (PONV), total tramadol consumption, and the need for additional analgesics during the 24-hour postoperative period were recorded. \u0000Results: Seventy patients who underwent LC participated in this study. The use of analgesic medications was statistically lower in group I than in the other group A. NRS scores between the IV ibuprofen and acetaminophen groups were statistically similar at 1, 2, 4, 6, 12, and 24 hours postoperatively (P>0.05). 24-hour opioid consumption was statistically significantly higher in group A than in group I (P0.05). PONV rates were similar in the ibuprofen and acetaminophen groups (P>0.05). ORAEs were similar between groups. \u0000Conclusion: Ibuprofen as part of tramadol-based multimodal analgesia reduced tramadol consumption compared to acetaminophen during the first 24 hours postoperatively following elective LC surgery. The IV ibuprofen-tramadol combination appeared superior to an acetaminophen-tramadol combination. ORAEs were similar in both groups.","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126670570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Anatomical Landmarks in Endonasal Endoscopic Optic Nerve Decompression Surgery: An Anatomical Study","authors":"Tuğba MORALI GÜLER, H. Başak, Yahya Efe Güner, M. Yilmaz, Yiğit Güngör, T. Aktürk, A. Cömert, G. Kahilogullari","doi":"10.18663/tjcl.1224324","DOIUrl":"https://doi.org/10.18663/tjcl.1224324","url":null,"abstract":"Aim \u0000Optic nerve decompression can be applied for many pathologies that affect the optic canal and the optic nerve. Optic nerve decompression via endonasal endoscopic method is very popular in nowadays with the developments in endoscopic surgery. \u0000Material and Methods \u0000In this study, the lateral opticocarotid recess (LOCR) and the medial opticocarotid recess (MOCR) which are important anatomical landmarks used during transsphenoidal approach to the opticocarotid region were evaluated. The relations of these anatomical landmarks with each other and with important surrounding landmarks such as optic nerve were examined. \u0000Results \u0000MOCR were observed in all cadavers on the right side and in 4 of 5 cadavers on the left side. The superior border of the LOCR was measured as 4.85±1.94 mm in average on the right side and 3.93±1.11 mm in average on the left side. The inferior border of the LOCR was measured as 4.72±2.11 mm in average on the right side and 3.98±1.67 mm in average on the left side. The linear distance between the LOCR and the MOCR was measured as 3.11±1.41 mm in average on the right side and 2.46±1.36 mm in average on the left side. \u0000Conclusion \u0000It is necessary for a safe surgery to reveal the anatomical landmarks and to know the detailed anatomy of this region during optic nerve decompression.","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"397 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132936012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitokondri Nakli ve Transferi, geçmişten gelecek beklentilere","authors":"Duygu Dayanir, Hakan Dayanir, Serdar Günaydın","doi":"10.18663/tjcl.1260343","DOIUrl":"https://doi.org/10.18663/tjcl.1260343","url":null,"abstract":"Hücre enerji eldesinde üstlendikleri eşsiz rolleri ile mitokondri yıllardır devam eden araştırmalar ile incelenmeye devam etmektedir. Mitokondriyal transfer hasarlanmış dokuya izole edilmiş olan mitokondrinin transfer edilme süreci olarak özetlenebilir. Bu sayede kalp hasarı olan doku gibi mitokondrial fonksiyonları bozulmuş bölgede mitokondrial disfonksiyon durmunun düzeltilmesi amaçlanmaktadır. Bu konu ile ilgili özellikle kalp dokusunda birçok çalışma olmakla beraber uygulanın miyokardial iskemi, reperfüzyon hasarı gibi süreçlerde koruyucu etkinliği araştırılmaya devam etmektedir. İzole edilen mitokondrin hasarlı dokuya aktarılmasında farklı prosedürler bulunmakla birlikte, birçok çalışmada uygulama ile ilgili olumlu sonuçlar bildirlmektedir. Derlemede literatürde bu alanda yapılmış olan çalışmalar incelenmekle birlikte konuya geniş bir penceren bakılması hedeflenmiştir.","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114178560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet effects on atrial premature complexes.","authors":"Y. Özen, A. Kuyumcu","doi":"10.18663/tjcl.1227763","DOIUrl":"https://doi.org/10.18663/tjcl.1227763","url":null,"abstract":"Aim: The aim of this study was to evaluate the relationship between atrial premature complexes (APC) and Mediterranean diet score. Rhythm disturbances in the heart significantly affect the quality of life of the patients. \u0000Material and Methods: This study was conducted on 50 patients with palpitations who were referred to the cardiology outpatient clinic and had more than 10000 APC per day as a result of a 24-hour holter, and 50 patients who presented with palpitations but had less than 10,000 APC in the holter. Diet quality was determined by scoring method (5, 6-9 and ≥10 points) ‘Mediterranean Diet Adaptation Scale’ and compared between groups. \u0000Results: There was no difference between the two groups in terms of clinical and demographic characteristics. Mediterranean diet scores were found lower in patients with APC’s ≥10.000/day (p","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127948310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the Castelli risk indeces and the presence and severity of ischemia in non-geriatric patients with suspected coronary artery disease","authors":"Birsen Doğanay","doi":"10.18663/tjcl.1252801","DOIUrl":"https://doi.org/10.18663/tjcl.1252801","url":null,"abstract":"Aims: This study aimed to investigate the relationship between ischemia severity and Castelli risk indices (CRI) levels in non-geriatric patients with suspected coronary artery disease (CAD) referred to myocardial perfusion scintigraphy (MPS) with gated single photon emission computed tomography (SPECT). \u0000Material and Methods: This retrospective study included 417 non-geriatric patients referred to SPECT MPS for suspected CAD at the Cardiology Clinic between January 2019 and January 2021. Patients were divided into normal, mild, moderate, and severe ischemia groups according to MPS. CRIs were calculated as follows: CRI-I = total cholesterol / HDL ratio; CRI-II = LDL / HDL ratio. \u0000Results: The CRIs levels were higher in ischemia group than non-ischemia group. Increase in CRI-II level was associated with increased ischemia severity. Increased CRI-II level was found to be an independent predictor of mild, moderate and severe ischemia group, but CRI-I was similar in moderate and severe ischemia groups. The threshold value of CRI-II for predicting the presence of ischemia was >2.1 (AUC ± SE = 0.787 ± 0.02, sensitivity = 79.5%, specificity = 71.4%). The threshold values of CRI-II showed a gradual increase in predicting the severity of ischemia. \u0000Conclusion: CRI-II offers offers gradually increasing threshold values in distinguishing patients with suspected CAD but without perfusion defects or determining its severity in the case of ischemia. CRI-II can be a potential screening tool for patients with suspected CAD and it can be used for risk stratification.","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"90 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132708467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VARİKOSELEKTOMİ OPERASYONU SONRASI İŞE GERİ DÖNÜŞ ZAMANI VE İŞ GÜNÜ KAYBI","authors":"Mehmet Emin Şi̇ri̇n, M. Yılmaz, M. Karaaslan","doi":"10.18663/tjcl.1255355","DOIUrl":"https://doi.org/10.18663/tjcl.1255355","url":null,"abstract":"Amaç: Varikoselektomi operasyonları çoğunlukla 20-35 yaşları arasında uygulanmaktadır. Bu yaş grubu aynı zamanda etkin iş gücü için de oldukça önemlidir. Varikoselektomide iş günü kaybı üzerine literatürde çalışma bulunmamaktadır. Bu çalışmamızla varikoselektomi ameliyatının iş günü kaybına etkisi üzerine farkındalık oluşturmak ve literatüre katkıda bulunmayı amaçladık. \u0000Gereç ve Yöntemler: Aksaray Özel İnova Hastanesi’nde 07.03.2019-14.10.2022 tarihleri arasında varikoselektomi yapılan 77 hasta çalışmaya dahil edildi. Varikoselektomi tek cerrah tarafından subinguinal yöntem kullanılarak, Carl-Zeiss operasyon mikroskopu (Carl Zeiss, Thornwood, NY) ile 10’luk büyütme altında uygulandı. Hastaların erken dönem komplikasyonları ve iş günü kaybı ameliyat sonrası 10. gün ve 1. ay kontrollerinde sorgulandı. Araştırma verilerinin istatistiksel analizi için Statistical Package for Social Sciences (SPSS), sürüm 22.0 (SPSS Inc. Chicago, ABD) bilgisayar paket programı kullanıldı. p 0,05). İş türü, medeni durum ve erken dönem komplikasyonların çeşitleri ile iş günü kaybı arasında istatistiksel anlamlı farklılık bulundu (p:0,014, p:0,03 ve p:0,02; sırasıyla). \u0000Sonuç: Mavi yakalı çalışanların varikoselektomi operasyonu sonrası beyaz yakalı çalışanlara göre işe dönüş zamanı birkaç gün daha uzun olmaktadır. Yaklaşık olarak varikoselektomi sonrası çalışanlar 15 gün sonra işbaşı yapabilmektedir. Bu konuda prospektif, daha büyük merkezlerin geniş vaka serilerine ihtiyaç olduğu kanaatindeyiz. \u0000Anahtar Kelimeler: iş günü kaybı; varikoselektomi; mikrocerrahi","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130610046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kronik Pulmoner Problemli Hastalarda Kostoklavikular Brakial Pleksus Bloğu􏰁nun􏰁 Diyafram Hareketi ve Analjeziye Etkileri: Retrospektif Analiz","authors":"Gökçen Emmez, İrfan Güngör, Ulunay Kanatli","doi":"10.18663/tjcl.1255472","DOIUrl":"https://doi.org/10.18663/tjcl.1255472","url":null,"abstract":"Amaç: ÇeşitIi seviyeIerden yapıIan Brakial pIeksus bIokIarı, postoperatif analjezi için artroskopik omuz cerrahisinde yaygın olarak kullanılmaktadır. Ancak, bloğun uygulandığı seviyeyle ilişkili yüksek hemidiyafragmatik paralizi insidansı, pulmoner fonksiyon bozukluğu olan hastalarda kullanımı sınırlamaktadır. Paradoksal olarak, pulmoner patolojili hastalarda analjezi için kullanılacak sistemik opioidlerin oksijenasyonu bozabileceği düşünüldüğünde analjezi yönetimleri özellikli hastalardır. Son araştırmalar frenik siniri koruyucu brakial pleksus blok yaklaşım alternatiflerini araştırmaktadır. Bu retrospektif çalışma ile, ultrason eşliğinde uygulanan kostoklavikular bloğun bilinen pulmoner patolojisi olan hastalardaki analjezik etkinliğinin ve diyafram fonksiyonlarına etkisinin araştırılması amaçlanmıştır. \u0000Gereç ve Yöntemler: Çalışmaya Ocak 2020-Temmuz 2022 tarihleri arasında, kronik puImoner probIemi oIan, kostokIavikuIar bIok ve geneI anestezi kombinasyonu iIe anestezi yönetimIeri gerçekIeştiriIen artroskopik omuz cerrahisi geçiren vakaIar dahiI ediIdi. Demografik veriler, cerrahi endikasyonlar, uygulanan genel anestezi yöntemi, komplikasyonlar/yan etkiler, VAS skorları, analjezi süreleri, uygulanan anestezi tekniği için hasta ve cerrah memnuniyeti ile diyafram fonksiyonları retrospektif olarak kayıtlardan incelendi. Blok uygulanan tarafta hemi- diyafram fonksiyonları; diyafram tutulumunun derecesi; > %75 ise “tam”, %25,1-74,9 ise “kısmi diyafram paralizisi” ve < %25 ise “paralizi yok” olarak değerlendirildi. \u0000Bulgular: Çalışmaya dahil edilen 21 hastanın dördü Bankart diğerleri rotator kaf rüptürü endikasyonuyla opere edilmişti. Hastalarda komplikasyon gözlenmedi. Anestezi tekniğiyle ilgili hem hasta (%71,4) hem cerrah (%100) memnuniyet oranları yüksekti. Diyafragma ekskürsiyon oranları %25’ten düşüktü ve dolayısıyla hemi-diyafragma paralizisinin gerçekleşmediği görüldü. Kostoklavikular blokla ortalama 470 dakika postoperatif analjezi sağlandı. \u0000Sonuçlar: Kostoklavikular blok, diyafram fonksiyonunu korurken etkin cerrahi ve postoperatif analjezi sağlamıştır. Bu nedenle pulmoner patolojisi olan artroskopik omuz cerrahisi geçirecek hastalarda geleneksel interskalen bloğa bir alternatif olarak düşünülebilir. \u0000Anahtar kelimeler: brakial pleksus blok; diyafram; analjezi; akciğer hastalıklarıAbstract \u0000Aim: Brachial plexus blocks are widely used for post-operative analgesia in shoulder surgery. The high risk of hemidiaphragmatic paralysis limits its use in patients with pulmonary dysfunction. In patients with pulmonary diseases, the management of pain requires special approaches since systemic opioids may also decrease oxygenation. Latest studies search for alternative methods for phrenic nerve preserving brachial plexus block. This retrospective study aim to analyze the analgesic efficacy and diaphraghmatic effects of ultrasonography guided costoclavicular block in patients with pulmonary diseases. \u0000Material and Methods: The study includes patients w","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125118235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fruktozla oluşturulan metabolik sendromda renin-anjiyotensin sistemi","authors":"A. Doğan, Fatma Akar","doi":"10.18663/tjcl.1242947","DOIUrl":"https://doi.org/10.18663/tjcl.1242947","url":null,"abstract":"Fruktozun işlenmiş gıdalarda yaygın olarak kullanılması insülin direnci, abdominal obezite, hipertrigliseridemi ve hipertansiyon ile karakterize olan metabolik sendromun artmasına neden olmaktadır. Fruktozla oluşturulan metabolik sendrom tip 2 diyabet, kardiyovasküler hastalıklar ve alkole bağlı olmayan yağlı karaciğer hastalığı (NAFLD) gibi çeşitli hastalıklara zemin hazırlamaktadır. Renin-anjiyotensin sistemi (RAS), kan basıncının düzenlenmesi, sıvı-elektrolit homeostazı, hücre büyümesi ve glikoz homeostazı üzerinde önemli rollere sahiptir. Renin ve anjiyotensin dönüştürücü enzim (ACE) tarafından anjiyotensinojenden türetilen anjiyotensin I (Agt I) ve anjiyotensin II (Agt II), RAS'ın temel bileşenleridir. Deneysel ve klinik çalışmalar, aşırı fruktoz tüketiminin RAS aktivasyonunu artırdığını göstermiştir. Fruktozla oluşturulan metabolik sendromda artan Agt II, insülin sinyal yolunu bozarak insülin direncini başlatmakta ve böylece tip 2 diyabet, hipertansiyon ve NAFLD'e zemin hazırlamaktadır. Anjiyotensin dönüştürücü enzim 2 (ACE2) tarafından Agt II'den oluşturulan anjiyotensin 1-7 (Agt 1-7), insülin direnci ve hepatik yağ birikimi üzerinde düzenleyici etkilerin yanı sıra Agt II'ye karşı dengeleyici etkilere sahiptir.","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129645534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achilles Tendon Surgery From The Perspective Of Patients: an Instagram Study","authors":"M. Özdemir, B. Birinci, Y. Yaradılmış, Mert Karaduman, A. S. Tarğal, B. Haberal","doi":"10.18663/tjcl.1231291","DOIUrl":"https://doi.org/10.18663/tjcl.1231291","url":null,"abstract":"Aim: The use of social media, especially Instagram, has become widespread in the medical field. The aim of this study was to evaluate Achilles tendon surgery from patients' perspectives by examining public posts on Instagram. \u0000Material and Methods: A retrospective analysis was made of the Instagram posts of patients with the hashtags #achillestendonsurgery and #achillestendonrepair between December 2018 and October 2021. In total, 234 posts (181 photographs, 53 videos) were evaluated and compared in terms of gender, sharing format (video, photo), sharing tone (negative, positive, neutral), content (activities of daily living, rehabilitation, cast/brace, hospital room, surgical site), country and popularity (the number of views for videos, the number of likes for photographs). \u0000Results: Posts in video format and a positive tone, posts on the rehabilitation process, and posts about male patients were found to have higher numbers of likes and views than other posts. The content of the shares were respectively; activity of daily living 36.8%(n=86), physical therapy 29.9%(n=70), cast/brace 20.1%(n=47), surgical site 7.7%(n=18), and hospital room 5.6%(n=13). The media tone of the posts was 40.2%(n=94) positive, 6.4%(n=15) negative, and 53.4%(n=125) neutral. \u0000Conclusions: Patients avoided making negative posts on their Instagram after Achilles tendon surgery, and often shared experiences of postoperative rehabilitation processes and daily living activities.","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134246559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the hemodynamic effects of etomidate-midazolam and ketamine-midazolam combinations in anesthesia induction in coronary artery bypass surgery","authors":"A. Camkıran Fırat, Ö. Kömürcü, N. Bayraktar, A. Sezgin, G. Arslan","doi":"10.18663/tjcl.1219943","DOIUrl":"https://doi.org/10.18663/tjcl.1219943","url":null,"abstract":"Aims: We aimed to compare the effects of anesthesia induction on hemodynamic parameters of ketamine-midazolam or etomidate-midazolam combinations and coronary artery bypass grafting surgery. \u0000Material and Methods: 40 adult patients undergoing CABG were randomly allocated into two groups for this prospective randomized double-blinded study. Ketamine group (n = 20) and Etomidate group (n = 20). Intraoperative and postoperative hemodynamic variables, adrenal gland functions and intensive care period were compared after anesthesia induction with etomidate and ketamine. \u0000Results: Perioperative hemodynamic parameters were not significantly different between the groups. Despite similar baseline measurements, cortisol levels were significantly higher 5 minutes after induction, during rewarming, and after ACTH stimulation test at postoperative day 1 in group ketamine than group etmidate. The groups were not significantly different in terms of duration of postoperative mechanical ventilation, frequency of postoperative delirium, and intensive care unit and hospital lengths of stay. \u0000Conclusion: Ketamine-midazolam combination is an acceptable alternative to etomidate-midazolam combination in terms of hemodynamic stability. Compared with the ketamine-midazolam combination, the etomidate-midazolam combination significantly decreased cortisol levels during the intraoperative and early postoperative periods","PeriodicalId":120468,"journal":{"name":"Turkish Journal of Clinics and Laboratory","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124339195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}