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[The synthesis, toxicological and comparative cytogenetic characteristics of the anticoagulant warfarin]. [抗凝血剂华法林的合成、毒理学和比较细胞遗传学特性]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
I Manolov, M Topashka-Ancheva, E Klouchek
{"title":"[The synthesis, toxicological and comparative cytogenetic characteristics of the anticoagulant warfarin].","authors":"I Manolov,&nbsp;M Topashka-Ancheva,&nbsp;E Klouchek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>4-hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1-benzopyran-2-one (warfarin) has been synthesised by an original method. The influence of a phase-transfer catalyst of ammonium type with alkyl substituents containing eight carbon atoms upon the reaction of Michael addition has been investigated. It has been found out that when elongating the hydrocarbon chain of the substituents to the nitrogen atom in the quaternary ammonium salt the yield of the product decreased. The acute (LD50) and subchronic (lasting for 30 days) toxicity was determined when taking warfarin orally. The experimental data show that LD50 is 500 mg/kg for mice and 420 mg/kg body mass for rats. The subchronic toxicity at experiments made with rabbits (each day taking orally respectively 25 and 100 mg/kg) does not reveal any humoral and tissue toxic influence of warfarin. The results from the comparative cytogenetic analysis of warfarin and Niffcumar are the basis of the conclusion cytogenetic analysis of warfarin and Niffcumar are the basis of the conclusion that warfarin damages chromosomes of mice's marrow cells (used as a model) less than Niffcumar. Moreover warfarin has a slight influence on these cells in the first place changing the orientation of chromosomes one towards the other and unlike other drugs it does not damage nuclear chromatin strongly.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 3-4","pages":"49-60"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18806195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Morphological and morphometric studies of the pancreas in type-2 diabetes mellitus]. [2型糖尿病胰腺的形态学和形态计量学研究]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
R Zhablenska, Ts Boshnakova, A Georgiev, P Petkov, A Popov
{"title":"[Morphological and morphometric studies of the pancreas in type-2 diabetes mellitus].","authors":"R Zhablenska,&nbsp;Ts Boshnakova,&nbsp;A Georgiev,&nbsp;P Petkov,&nbsp;A Popov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors investigated histologically and immunohistochemically 60 cases with diabetes mellitus type 2. By means of the morphometric method of Weibel et al. (1969) they established diminished volume density of the insular tissue in total pancreas. The morphologic and morphometric data revealed evidence that diabetes mellitus most probably presented a heterogeneous group of pancreatic lesions manifested by disturbances of carbohydrate homeostasis.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 3-4","pages":"16-28"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Polypous endocarditis of the tricuspid valve. The morphological changes in the heart and lung in one case]. 三尖瓣息肉性心内膜炎。心、肺各1例形态学改变[d]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
S Nachev, R Takov
{"title":"[Polypous endocarditis of the tricuspid valve. The morphological changes in the heart and lung in one case].","authors":"S Nachev,&nbsp;R Takov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of polypous endocarditis which affects the tricuspid valve and whose genesis remains unclear (a septic state, an idiopathic disease?) is described. Clinically the disease has taken its course as a chronically recurring form of pulmonary thromboembolism. Morphologically it concerns to a massive fibroplastic verrucous endocarditis of the tricuspid valve and a more slightly expressed similar process in the wall of the right atrium and ventricle, combined with a significant fibrosis of the myocardium. The death has come from a massive thrombotic embolism in the two branches of the pulmonary artery on the background of a great number of small thromboembolic and hemorrhagenic infarctions with a different duration in the two lobes of the lung, which lead to an adaptable reconstruction of many lung vessels. The presence of a discrete affection of the aortic valve according to a rheumatic type and the combination of the disease, in the described case, with essential hypertension and thrombophlebitis undergone in the past, give a reason to discuss the possibility of taking into account these diseases in etiopathogenesis of the described myocardiopathy.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 3-4","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18806194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lung metastases from tumors at different sites]. [不同部位肿瘤的肺转移]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
L Krŭsteva-Sedmakova, P Uzunov, I Boneva, V Vlasov
{"title":"[Lung metastases from tumors at different sites].","authors":"L Krŭsteva-Sedmakova,&nbsp;P Uzunov,&nbsp;I Boneva,&nbsp;V Vlasov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparative study of necropsy material is carried out for the period of 1974-1983. For these ten years 11603 autopsies are performed. In 222 cases neoplastic processes with different lung metastases are obligatory, which makes 1.8% of total number of cases. The primary sites of these metastases are as follows: tumor of the stomach (26), breast (33), bile duct (10), bile ways (3), liver (13), large intestine (30), incretory glands (31), etc. The morphological evolution shows that the histologic type of the primary tumors varies (carcinomas, malignant lymphomas, teratocarcinomas, sarcomas, neuroblastomas, etc.). In some cases (carcinomas of the kidneys and liver, sarcomas of the bones) the histologic type of the primary tumor is identical to that of the Metastatic processes in the lungs. In some of the lung metastases however there are differences in the histological structure compared to the primary tumors. A clinical morphological comparative study is performed.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 3-4","pages":"94-104"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18806199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The microcomputer study and processing of the values of the blood pressure and intersystolic interval in laboratory animals]. 实验动物血压和收缩间期值的微机研究与处理。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
K Simeonov, M Daskalova, I Lambev, I Krushkov
{"title":"[The microcomputer study and processing of the values of the blood pressure and intersystolic interval in laboratory animals].","authors":"K Simeonov,&nbsp;M Daskalova,&nbsp;I Lambev,&nbsp;I Krushkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A system is created for study of the agents, affecting the arterial pressure and baroreflectory sensitivity, which comprises:transducer for arterial pressure Statham P23 ID, connected to a polygraph Biomedica O.T.E.; eight-bite analogous-numerical transformer; microcomputer, compatible to Apple 2+; two diskette devices and printer. The arterial pressure of the lab animals (rats, rabbits, cats) is directly measured in a. carotis communis by means of the transducer and is recorded on the polygraph. For the system a computer program is designed which allows archivation of the primary experimental data; automatic and precise determination of the momentary values of the systolic and diastolic arterial pressure and intersystolic interval; determination of the baroreflectory sensitivity by means of linear regressive analyses; printing of the results under the form of diagrams and tables. By means of this system much time is spared, related to the accounting and handling of the experimental data.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 1-2","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19247193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The immunobiological functions of human ABO (H)-system blood-group antigens]. [人ABO (H)血型抗原的免疫生物学功能]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
V Sarafian, A Popov, Kh Taskov
{"title":"[The immunobiological functions of human ABO (H)-system blood-group antigens].","authors":"V Sarafian,&nbsp;A Popov,&nbsp;Kh Taskov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The human ABO (H) blood group antigens are genetically determined carbohydrate structures found in different cells and tissues. The modulation in their expression in the course of human onto- and oncogenesis gives grounds for speculations concerning the role of ABO (H) antigens as molecules, participating in cell interactions, adhesion and inhibition events, as well as in tumor metastases. The deletion of antigenic determinants observed in a number of human carcinomas, and the epitope homology between the blood group antigens and the carcinoembryonic antigen, focuses on clarifying the diagnostic and prognostic value of the ABO (H) antigens as tumor-associated markers.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 3-4","pages":"105-16"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The preparation of materials and the isolation of human genomic DNA for analysis]. 【材料的制备及分析用人类基因组DNA的分离】。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
V Ganev, P Georgiev, L Sirakov
{"title":"[The preparation of materials and the isolation of human genomic DNA for analysis].","authors":"V Ganev,&nbsp;P Georgiev,&nbsp;L Sirakov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The work reviews the usual and most convenient human samples (blood cells, fibroblasts, etc.) for extraction of DNA, storage conditions, DNA extraction approaches, and the criteria for assessment of quality and suitability of the extracted DNA for subsequent analysis. The aim of this work is to make professionals from different laboratory disciplines aware of the basic approaches to DNA sampling and storage in order to promote their further involvement in diagnostics and research based on DNA technology.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 3-4","pages":"116-27"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vasopressin as a neurotransmitter and neuromodulator]. 加压素作为一种神经递质和神经调节剂。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
G Kosekova, R Paneva, L Sirakov
{"title":"[Vasopressin as a neurotransmitter and neuromodulator].","authors":"G Kosekova,&nbsp;R Paneva,&nbsp;L Sirakov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent data about the antidiuretic hormone arginine vasopressin (AVP) are reviewed which show that except its well known peripheral endocrine functions, it has another not less important function as a neurotransmitter and neuromodulator in the central nervous system. AVP facilitates learning and memory consolidation. Data are also presented about the primary structure of AVP precursor and the sites of its synthesis, as well as about the AVP receptors and the mechanism of its action in different brain areas. Data are given about the ways of inactivation of its second messengers inositol-1,4,5-triphosphate and diacylglycerol. There are also data about AVP antipyretic effect in septum. A hypothesis is presented that the action of some nonsteroid antipyretic substances is mediated through V1-receptors of AVP in septum.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 1-2","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18900110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of anionic complexes on cytochrome c oxidation by cytochrome c oxidase]. [阴离子配合物对细胞色素c氧化酶氧化的影响]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
M Mitovska, R Paneva, K Dancheva
{"title":"[The effect of anionic complexes on cytochrome c oxidation by cytochrome c oxidase].","authors":"M Mitovska,&nbsp;R Paneva,&nbsp;K Dancheva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of different buffer anions on the maximal velocity (Vmax) and Michaelis constant (Km) of the first reaction between horse cytochrome c and beef cytochrome c oxidase was studied. The Michaelis constant for the high affinity phase varies little as the buffer anions borate, phosphate, succinate and citrate were employed, but Vmax varies significantly. At the ionic strength I = 0.1 and pH 7.4 the Vmax increases in the order as following: borate < phosphate < succinate < > citrate. citrate. The differences in maximal activities in the presence of the anions may result from the changes in anion binding side on cytochrome c that affect its interaction with cytochrome c oxidase. The effect of the phosphate, succinate and citrate anions on the electron transfer reaction between cytochrome c and cytochrome c oxidase is important as a control of the respiration process in mitochondria at physiological conditions.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 1-2","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19247191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Methemoglobinemias. Cytochrome b5-reductase deficiency]. (高铁血红蛋白症。细胞色素b5还原酶缺乏症]。
Eksperimentalna meditsina i morfologiia Pub Date : 1993-01-01
D T Thu, L Damianova
{"title":"[Methemoglobinemias. Cytochrome b5-reductase deficiency].","authors":"D T Thu,&nbsp;L Damianova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the paper are considered the basic mechanisms, leading to accumulation of methemoglobin in the red blood cells. The inherited methemoglobinaemia, due to enzymatic failure of cytochrome B5-reductase is considered.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"31 1-2","pages":"42-50"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19247194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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