β-catenin repositions over time.

IF 9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Systems Pub Date : 2023-07-19 DOI:10.1016/j.cels.2023.06.008

Sarah M Leichter, Steven Henikoff

引用次数: 0

Abstract

How β-catenin, the nuclear activator of the Wnt pathway, affects the chromatin environment of its targets is unknown. Over a time course of stimulation, β-catenin repositions itself around the genome in a cell-type-specific manner, eliciting transient chromatin changes in differentiated cells and progressive shaping of undifferentiated cells.

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随着时间的推移，β-catenin 会重新定位。

Wnt通路的核激活因子β-catenin如何影响其靶标的染色质环境尚不清楚。在一段时间的刺激过程中，β-catenin 以细胞类型特异性的方式在基因组周围重新定位，在分化细胞中引起瞬时染色质变化，并在未分化细胞中逐渐形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Systems Medicine-Pathology and Forensic Medicine

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

42 days

期刊介绍： In 2015, Cell Systems was founded as a platform within Cell Press to showcase innovative research in systems biology. Our primary goal is to investigate complex biological phenomena that cannot be simply explained by basic mathematical principles. While the physical sciences have long successfully tackled such challenges, we have discovered that our most impactful publications often employ quantitative, inference-based methodologies borrowed from the fields of physics, engineering, mathematics, and computer science. We are committed to providing a home for elegant research that addresses fundamental questions in systems biology.