{"title":"The Impact of Crohn's Perianal Fistula on Quality of Life: Results of an International Patient Survey.","authors":"Antonino Spinelli, Henit Yanai, Paolo Girardi, Slobodan Milicevic, Michele Carvello, Annalisa Maroli, Luisa Avedano","doi":"10.1093/crocol/otad036","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Crohn's perianal fistula is a disabling manifestation of Crohn's disease. However, the additional burden of perianal fistula on patients with only Crohn's disease remains to be addressed. This patient-reported survey considered outcomes of two domains: \"diagnosis\" (eg, symptoms) and \"living with the disease\" (eg, quality of life, well-being, and relationships).</p><p><strong>Methods: </strong>Patients with perianal fistula and Crohn's disease completed an online, self-selective, anonymous, 46-item survey available in 11 languages hosted on the European Federation of Crohn's & Ulcerative Colitis Associations and national patient association websites. The survey was conducted between July and December 2019 in Europe and other regions. Likert scales and closed questions were used to assess outcomes.</p><p><strong>Results: </strong>Of the 820 respondents with Crohn's disease (67.2% women; median age, 40.0 years), 532 (64.9%) reported the presence of perianal fistula. Patients with perianal fistula reported a greater impact on overall quality of life (<i>P</i> < .001), well-being (<i>P</i> < .001), relationships (<i>P</i> < .001), social life (<i>P</i> = .001), and work life (<i>P</i> = .012) than patients with only Crohn's disease.</p><p><strong>Conclusions: </strong>Perianal fistulas impact several domains of the life of patients with Crohn's disease. These results may help healthcare practitioners plan therapeutic strategies that address the symptomatic and psychological burden experienced by patients with perianal fistulizing Crohn's disease.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390083/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crohn's & Colitis 360","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/crocol/otad036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 2
Abstract
Background: Crohn's perianal fistula is a disabling manifestation of Crohn's disease. However, the additional burden of perianal fistula on patients with only Crohn's disease remains to be addressed. This patient-reported survey considered outcomes of two domains: "diagnosis" (eg, symptoms) and "living with the disease" (eg, quality of life, well-being, and relationships).
Methods: Patients with perianal fistula and Crohn's disease completed an online, self-selective, anonymous, 46-item survey available in 11 languages hosted on the European Federation of Crohn's & Ulcerative Colitis Associations and national patient association websites. The survey was conducted between July and December 2019 in Europe and other regions. Likert scales and closed questions were used to assess outcomes.
Results: Of the 820 respondents with Crohn's disease (67.2% women; median age, 40.0 years), 532 (64.9%) reported the presence of perianal fistula. Patients with perianal fistula reported a greater impact on overall quality of life (P < .001), well-being (P < .001), relationships (P < .001), social life (P = .001), and work life (P = .012) than patients with only Crohn's disease.
Conclusions: Perianal fistulas impact several domains of the life of patients with Crohn's disease. These results may help healthcare practitioners plan therapeutic strategies that address the symptomatic and psychological burden experienced by patients with perianal fistulizing Crohn's disease.
背景:克罗恩肛周瘘是克罗恩病的致残表现。然而，仅克罗恩病患者肛周瘘的额外负担仍有待解决。这项由患者报告的调查考虑了两个领域的结果:“诊断”(如症状)和“与疾病共存”(如生活质量、幸福感和人际关系)。方法:患有肛周瘘和克罗恩病的患者在欧洲克罗恩病和溃疡性结肠炎协会联合会和国家患者协会网站上以11种语言完成了一项在线、自我选择、匿名、46项的调查。该调查于2019年7月至12月在欧洲和其他地区进行。李克特量表和封闭式问题用于评估结果。结果:820例克罗恩病患者中(67.2%为女性;中位年龄40.0岁，532例(64.9%)报告存在肛周瘘。与仅患有克罗恩病的患者相比，肛周瘘患者对总体生活质量(P P P = .001)和工作寿命(P = .012)的影响更大。结论:肛周瘘管影响克罗恩病患者生活的几个方面。这些结果可能有助于保健医生计划治疗策略，解决症状和心理负担的患者经历肛周瘘管性克罗恩病。
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