Bridging mouse and human anatomies; a knowledge-based approach to comparative anatomy for disease model phenotyping.

IF 2.7 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jesús Ruberte, Paul N Schofield, John P Sundberg, Alfonso Rodriguez-Baeza, Ana Carretero, Colin McKerlie
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引用次数: 2

Abstract

The laboratory mouse is the foremost mammalian model used for studying human diseases and is closely anatomically related to humans. Whilst knowledge about human anatomy has been collected throughout the history of mankind, the first comprehensive study of the mouse anatomy was published less than 60 years ago. This has been followed by the more recent publication of several books and resources on mouse anatomy. Nevertheless, to date, our understanding and knowledge of mouse anatomy is far from being at the same level as that of humans. In addition, the alignment between current mouse and human anatomy nomenclatures is far from being as developed as those existing between other species, such as domestic animals and humans. To close this gap, more in depth mouse anatomical research is needed and it will be necessary to extent and refine the current vocabulary of mouse anatomical terms.

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连接小鼠和人体解剖;以知识为基础的方法来比较解剖学疾病模型表型。
实验小鼠是用于研究人类疾病的最重要的哺乳动物模型,在解剖学上与人类密切相关。虽然人类历史上关于人体解剖学的知识一直在收集,但第一次对小鼠解剖学的全面研究是在不到60年前发表的。在此之后,最近又出版了几本关于老鼠解剖的书籍和资源。然而,到目前为止,我们对小鼠解剖学的理解和认识还远远没有达到与人类相同的水平。此外,目前小鼠和人类解剖学命名法之间的一致性远没有其他物种(如家畜和人类)之间的一致性那么发达。为了缩小这一差距,需要更深入的小鼠解剖学研究,有必要扩大和完善现有的小鼠解剖学术语词汇。
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来源期刊
Mammalian Genome
Mammalian Genome 生物-生化与分子生物学
CiteScore
4.00
自引率
0.00%
发文量
33
审稿时长
6-12 weeks
期刊介绍: Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.
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