Practical Manipulation for the Preparation of Mesoporous Silica Nanoparticles for Drug Delivery Vehicles.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201819666220901105102

Minki Kim, Heeok Shim, Young-Guk Na, Hong-Ki Lee, Jong-Suep Baek, Cheong-Weon Cho

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引用次数: 0

Abstract

Background: Optimization of MSNs is the most important process for efficient and safe drug delivery systems.

Objective: In this study, the physicochemical properties of MSNs were evaluated using various compositions of individual reagents.

Methods: MSNs were synthesized according to a modified Stöber method. The physicochemical properties of MSNs were evaluated. Spherical uniform particles were observed in the scanning electron microscope (SEM) and transmission electron microscopy (TEM) image and the meso-structure of MSNs was confirmed. The amorphous and specific hexagonal structure of MSNs was confirmed through Xray diffraction (XRD) and SAXRD.

Results: The particle size and surface area according to changes in amounts of reagents ranged from 34.5 ± 2.3 to 216.0 ± 17.1 nm and from 549.79 to 1154.26 m²/g, respectively. A linear relationship was found between the surface area of MSNs and the adsorption rate of methylene blue (MB). MSNs exhibited no apparent cytotoxic effect on Caco-2 cell up to 200 μg/mL. The amounts of tetramethyl ammonium silicate and tetraethyl ortho silicate (TEOS), NaOH, and hexadecyl trimethyl ammonium bromide (CTAB) were adjusted to control the particle size and surface area of MSNs, and it was found that the amounts of synthetic reagents affected the physicochemical properties such as particle size and surface area of MSNs. MSNs with a large surface area adsorbed a large amount of MB.

Conclusion: These results indicated that drug adsorption is related to the surface area of MSNs. MSNs did not show cytotoxicity to Caco-2 cells. MSNs may be a promising nanomaterial that could be applied as a carrier for various drugs.

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用于药物递送载体的介孔二氧化硅纳米颗粒制备的实际操作。

背景:msn的优化是高效、安全给药系统的重要环节。目的:本研究采用不同的试剂组成对msn的理化性质进行了评价。方法:采用改进的Stöber法制备msn。并对其理化性质进行了评价。扫描电镜(SEM)和透射电镜(TEM)观察到球状均匀颗粒，并证实了微孔微球的细观结构。通过x射线衍射(XRD)和SAXRD证实了msn的非晶态和特定的六边形结构。结果:随着试剂用量的变化，其粒径范围为34.5±2.3 ~ 216.0±17.1 nm，比表面积范围为549.79 ~ 1154.26 m2/g。结果表明，msn的表面积与亚甲基蓝(MB)的吸附率呈线性关系。当浓度达到200 μg/mL时，MSNs对Caco-2细胞无明显的细胞毒作用。通过调整四甲基硅酸铵和四乙基邻基硅酸铵(TEOS)、氢氧化钠(NaOH)和十六烷基三甲基溴化铵(CTAB)的用量来控制微孔微球的粒径和表面积，发现合成试剂的用量对微孔微球的粒径和表面积等理化性质有影响。结论:这些结果表明，药物吸附与msn的表面积有关。msn对Caco-2细胞无细胞毒性。微孔微球可能是一种很有前途的纳米材料，可以作为各种药物的载体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.