Dynamic changes and clinic significance of serum high mobility group box 1 in patients with total hip arthroplasty.

IF 0.5 4区医学 Q4 SURGERY

Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000238

Guangfu Zhou, Mao Liu, Xulin Wu, Bensen Tang

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引用次数: 1

Abstract

Background: Deeper understanding on the risk factors and seeking potential predicted biomarkers for prognosis of total hip arthroplasty (THA) patients are of great significance. Limited researches focused the correlation between high mobility group box protein-1 (HMGB1) and the prognosis of THA patients.

Objective: The objective of this study was to investigate the role of HMGB1 and inflammatory factors in patients underwent total hip arthroplasty (THA).

Methods: The present prospective study enrolled 208 THA patients who went to our hospital during January 2020 to January 2022. Serum levels of HMGB1, C-reactive protein (CRP), interleukin-1b (IL-1β), and IL-6 were detected at the admission, 1 day, 3 days, 7 days, 30 days, and 90 days after surgery. The levels of Harris score, Fugl-Meyer, 36-item short-form health survey (SF-36), and Pittsburgh sleep quality index (PSQI) were detected on 90 days after surgery in two groups. Receiver operating characteristic curve (ROC) was performed for analyzing the diagnostic value of HMGB1 and logistic regression model was used for identifying the risk factor for poor prognosis of THA patients.

Results: Serum levels of HMGB1 and inflammatory factors increased after surgery compared with the baselines. A positive correlation was found between HMGB1 and CRP on 1 day after surgery, and positive correlations were found among HMGB1, IL-1β, and IL-6 on 3 day after surgery. Besides, low HMGB1 reduced the incidence of post-operative complications and improved prognosis of THA patients.

Conclusion: Serum HMGB1 was correlated with inflammatory factors and the prognosis of THA patients.

查看原文本刊更多论文

全髋关节置换术患者血清高迁移率组1的动态变化及临床意义。

背景:深入了解全髋关节置换术(THA)患者的危险因素，寻找潜在的预测预后的生物标志物具有重要意义。有限的研究集中在高迁移率群盒蛋白-1 (HMGB1)与THA患者预后的相关性。目的:本研究的目的是探讨HMGB1和炎症因子在全髋关节置换术(THA)患者中的作用。方法:本前瞻性研究纳入2020年1月至2022年1月在我院就诊的208例THA患者。分别于入院时、术后第1天、第3天、第7天、第30天、第90天检测血清HMGB1、c反应蛋白(CRP)、白细胞介素-1b (IL-1β)、IL-6水平。检测两组患者术后90天Harris评分、Fugl-Meyer、36项健康问卷调查(SF-36)和匹兹堡睡眠质量指数(PSQI)水平。采用受试者工作特征曲线(Receiver operating characteristic curve, ROC)分析HMGB1的诊断价值，采用logistic回归模型识别THA患者预后不良的危险因素。结果:术后血清HMGB1及炎性因子水平较基线升高。术后第1天HMGB1与CRP呈正相关，术后第3天HMGB1与IL-1β、IL-6呈正相关。此外，低HMGB1降低了THA患者术后并发症的发生率，改善了预后。结论:血清HMGB1与THA患者的炎症因子及预后相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.