Progress in the application of 3D-printed sodium alginate-based hydrogel scaffolds in bone tissue repair

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2023-09-01 DOI:10.1016/j.bioadv.2023.213501

Xulin Hu , Zhen Zhang , Haoming Wu , Shuhao Yang , Weiming Zhao , Lanyu Che , Yao Wang , Jianfei Cao , Kainan Li , Zhiyong Qian

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引用次数: 7

Abstract

In recent years, hydrogels have been widely used in the biomedical field as materials with excellent bionic structures and biological properties. Among them, the excellent comprehensive properties of natural polymer hydrogels represented by sodium alginate have attracted the great attention of researchers. At the same time, by physically blending sodium alginate with other materials, the problems of poor cell adhesion and mechanical properties of sodium alginate hydrogels were directly improved without chemical modification of sodium alginate. The composite blending of multiple materials can also improve the functionality of sodium alginate hydrogels, and the prepared composite hydrogel also has a larger application field. In addition, based on the adjustable viscosity of sodium alginate-based hydrogels, sodium alginate-based hydrogels can be loaded with cells to prepare biological ink, and the scaffold can be printed out by 3D printing technology for the repair of bone defects. This paper first summarizes the improvement of the properties of sodium alginate and other materials after physical blending. Then, it summarizes the application progress of sodium alginate-based hydrogel scaffolds for bone tissue repair based on 3D printing technology in recent years. Moreover, we provide relevant opinions and comments to provide a theoretical basis for follow-up research.

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3D打印海藻酸钠水凝胶支架在骨组织修复中的应用进展

近年来，水凝胶作为一种具有优异仿生结构和生物性能的材料，在生物医学领域得到了广泛应用。其中，以海藻酸钠为代表的天然聚合物水凝胶优异的综合性能引起了研究人员的高度关注。同时，通过将海藻酸钠与其他材料物理共混，在没有对海藻酸盐进行化学改性的情况下，直接改善了海藻酸盐水凝胶的细胞粘附性和力学性能差的问题。多种材料的复合共混也可以提高海藻酸钠水凝胶的功能性，制备的复合水凝胶也有更大的应用领域。此外，基于海藻酸钠基水凝胶的可调粘度，海藻酸盐基水凝胶可以装载细胞制备生物墨水，并可以通过3D打印技术打印出支架，用于修复骨缺损。本文首先综述了海藻酸钠等材料经物理共混后性能的改善。然后，总结了近年来基于3D打印技术的海藻酸钠水凝胶支架在骨组织修复中的应用进展。此外，我们还提供了相关的意见和评论，为后续研究提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!