Antithrombin Deficiency: Frequency in Patients with Thrombosis and Thrombophilic Families.

Q3 Medicine

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI:10.14712/18059694.2023.10

Maria Anna Pejková, Eva Ivanová, Petr Sadílek, Radovan Malý, Zuzana Thibaud, Petr Dulíček

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引用次数: 0

Abstract

Purpose: Antithrombin (AT) deficiency is a well-known inherited risk factor for venous thromboembolism (VTE). However, F V Leiden and F II20210a mutations have drawn much more attention in the recent years. Therefore, we have decided to analyze the frequency of antithrombin deficiency in different cohorts of patients and tried to formulate indications for its testing.

Results: Antithrombin deficiency was found in 4% of patients with recurrent VTE ≤ 50 years of age with, in 1% of patients with splanchnic vein thrombosis and in 2% of cases associated with combined oral contraceptives (COC) use or pregnancy. In patients with central venous thrombosis, antithrombin deficiency was not found.

Recommendation: We consider antithrombin testing useful in patients with thrombosis occuring up to 45 years of age without any risk factors. Namely, females with VTE in pregnancy and puerperium should be tested as well as females with thrombosis on COC, if VTE occurred within the first year of their use.

Conclusion: In spite of degressive interest in thrombophilia work up, we still consider antithrombin testing useful in defined clinical situations.

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抗凝血酶缺乏:在血栓患者和亲血栓家庭中的频率。

目的:抗凝血酶(AT)缺乏是众所周知的静脉血栓栓塞(VTE)的遗传危险因素。然而，近年来，fv Leiden和F II20210a突变引起了越来越多的关注。因此，我们决定分析不同队列患者中抗凝血酶缺乏的频率，并试图制定其检测的适应症。结果:在年龄≤50岁的复发性静脉血栓栓塞患者中，4%的患者存在抗凝血酶缺乏，1%的患者存在植静脉血栓形成，2%的患者存在联合口服避孕药(COC)使用或妊娠相关。在中心静脉血栓患者中，未发现抗凝血酶缺乏。建议:我们认为抗凝血酶检测对45岁以下无任何危险因素的血栓患者有用。也就是说，在妊娠期和产褥期有静脉血栓栓塞的女性，以及在COC上有血栓形成的女性，如果静脉血栓栓塞在使用的第一年发生，都应该进行检测。结论:尽管对血栓形成的兴趣逐渐增加，我们仍然认为抗凝血酶检测在明确的临床情况下是有用的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica (Hradec Kralove) Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."