Genome-wide association study of preterm birth and gestational age in a Japanese population.

IF 1 Q4 GENETICS & HEREDITY
Keita Hasegawa, Natsuhiko Kumasaka, Kazuhiko Nakabayashi, Hiromi Kamura, Kayoko Maehara, Yoshifumi Kasuga, Kenichiro Hata, Mamoru Tanaka
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Abstract

Preterm birth (PTB), defined as the birth of a baby at <37 weeks of gestation, is known to be the main cause of neonatal morbidity and mortality. Here, we report genetic associations between preterm birth and gestational age in a Japanese population. We conducted a genome-wide association study (GWAS) of 384 cases who delivered prematurely and 644 controls and considered gestational age as a quantitative trait in 1028 Japanese women. Unfortunately, we were unable to identify any significant variants associated with PTB or gestational age using the current sample. We also examined genetic associations previously reported in European populations and identified no associations, even with the genome-wide subthreshold (p value < 10-6). This data report aims to provide summary statistics of current GWASs on PTB in a Japanese population for future meta-analyses of genetics and PTB with larger sample sizes.

Abstract Image

Abstract Image

Abstract Image

日本人群早产与胎龄的全基因组关联研究。
早产(PTB),定义为婴儿在-6)时出生。本数据报告旨在提供目前日本人群中有关早产儿的基因组研究的汇总统计数据,以便将来对样本量更大的遗传学和早产儿进行荟萃分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human Genome Variation
Human Genome Variation Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
2.30
自引率
0.00%
发文量
39
审稿时长
13 weeks
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