DNA Fragility and Repair: Some Personal Recollections.

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2023-06-20 DOI:10.1146/annurev-biochem-071322-020214

Tomas Robert Lindahl

引用次数: 0

Abstract

In this autobiographical article, I reflect on my Swedish background. Then I discuss endogenous DNA alterations and the base excision repair pathway and alternative repair strategies for some unusual DNA lesions. Endogenous DNA damage, such as loss of purine bases and cytosine deamination, is proposed as a major source of cancer-causing mutations.

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DNA的脆弱和修复:一些个人回忆。

在这篇自传体文章中，我反思了我的瑞典背景。然后我讨论了内源性DNA改变和碱基切除修复途径以及一些不寻常的DNA损伤的替代修复策略。内源性DNA损伤，如嘌呤碱基丢失和胞嘧啶脱胺，被认为是致癌突变的主要来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.