Analysis of Huntington's disease transgenic mice based on “Quinolinate Hypothesis”

T. Imai , K. Kobayashi , Y. Arii , E. Sugimoto , A. Okuno , K. Shibata , S.-I. Fukuoka
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Abstract

Enzymes related to quinolinate metabolism in the brain of Huntington's disease transgenic mice were investigated. Elevated levels of quinolinate were suggested in the diseased brains, supporting quinolinate hypothesis.

基于“喹啉假说”的亨廷顿病转基因小鼠分析
研究了亨廷顿氏病转基因小鼠脑内与喹啉酸盐代谢相关的酶。在患病的大脑中发现了高水平的喹啉酸,支持了喹啉酸假说。
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