[Emergency detection of HIV infection in patients consulting for conditions potentially related to occult infection: Initial results of the "Urgències VIHgila" program].

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-04-01 DOI:10.37201/req/085.2022

O Miró, E Miró, M Carbó, M Saura, A Rebollo, R de Paz, J M Guardiola, A Smithson, D Iturriza, C Ramió Lluch, C Leey, J I Ferro, A Villamor, E Gené

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引用次数: 2

Abstract

Objective: To estimate the prevalence of unknown HIV infection in patients who consulted in hospital emergency services (ED) for conditions defined in the SEMES-GESIDA Consensus Document (DC), evaluate the efficiency of its im-plementation and investigate the efficiency of HIV serology determination in other conditions.

Methods: Results were reviewed in 10 Catalan EDs for 12 months (July-21-June-22) after implementing CD recommendations: request HIV serology in case of suspected sexually transmitted infection, chemsex, post-exposure prophylaxis (PEP), mononucleosis syndrome, community pneumonia (18-65 y-o) or herpes zoster (18-65 y-o). Other reasons for request were included. Prevalence (%) of global seropositivity and for each circumstance was calculated, with a 95% confidence interval (95%CI). The efficient strategy was considered if the lower limit of the CI95%>0.1%.

Results: A total of5,107 HIV serologies were performed: 2,847(56%) in situations specified in CD, and 2,266 (44%) in other 138 circumstances. Forty-eight unknown HIV infections were detected (prevalence=0.94%;95%CI=0.69-1.24). The prevalence was somewhat higher in DC requests (30 cas-es 1.12%) than the rest (18 cases 0.71%; p=0.16). The individualized prevalence of CD reasons ranged between 7.41% (95%CI=0.91-24.3) in chemsex and 0.42% 95%CI=0.14-0.98) in PPE, always efficient except herpes zoster (0.76%; CI95%=0.02-4.18). In other reasons, cases were detected in 12 circumstances, and in four the determination could be efficient: lymphopenia (10%;CI95%=0.25-44.5), fever with polyarthralgia-polyarthritis (7.41%;CI95% =0.91-24.3), behavioral alteration-confusion-encephalopathy (3.45%;95%CI=0.42-11.9) and fever of unknown origin (2.50%;95%CI=0.82-5.74).

Conclusions: The determination of HIV serology in HES in the processes defined by DC SEMES-GESIDA is efficient. Some circumstances are identified that could be added to those previously contemplated to increase efficiency.

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[在咨询可能与隐性感染有关的情况的患者中紧急检测艾滋病毒感染:“紧急VIHgila”计划的初步结果]。

目的:估计因《sems - gesida共识文件》(DC)定义的疾病到医院急诊就诊的患者中未知HIV感染的患病率，评估其实施效率，并调查其他情况下HIV血清学检测的效率。方法:对10例加泰罗尼亚ed实施CD建议后12个月(7月-21日-6月22日)的结果进行回顾:怀疑性传播感染的患者要求进行HIV血清学检查、化学行为、暴露后预防(PEP)、单核细胞增多症综合征、社区肺炎(18-65岁)或带状疱疹(18-65岁)。提出请求的其他理由也包括在内。计算每种情况下全球血清阳性的患病率(%)，95%置信区间(95% ci)。如果CI95%>0.1%，则考虑有效策略。结果:共进行了5107例HIV血清学检查:2847例(56%)在CD指定的情况下，2266例(44%)在其他138种情况下。检出48例未知HIV感染(患病率=0.94%;95%CI=0.69-1.24)。DC请求的患病率(30例1.12%)略高于其他(18例0.71%);p = 0.16)。在化学性别中，CD原因的个体化患病率为7.41% (95%CI=0.91-24.3)，在PPE中为0.42% (95%CI= 0.14-0.98)，除带状疱疹(0.76%;CI95% = 0.02 - -4.18)。在其他12种情况下检测到病例，其中4种诊断有效:淋巴细胞减少(10%，CI95%=0.25-44.5)、发热伴多关节痛-多关节炎(7.41%，CI95%= 0.91-24.3)、行为改变-精神错乱-脑病(3.45%，95%CI=0.42-11.9)和不明原因发热(2.50%，95%CI=0.82-5.74)。结论:在DC - sems - gesida定义的过程中检测HES的HIV血清学是有效的。还确定了一些可以添加到先前考虑的情况中以提高效率的情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.