Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2024-06-01 Epub Date: 2023-03-27 DOI:10.1177/19476035231163273

Arya Amirhekmat, Wendy E Brown, Evelia Y Salinas, Jerry C Hu, Kyriacos A Athanasiou, Dean Wang

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引用次数: 0

Abstract

Objective: Fibrin sealants are routinely used for intra-articular surgical fixation of cartilage fragments and implants. However, the mechanical properties of fibrin sealants in the context of cartilage repair are unknown. The purpose of this study was to characterize the adhesive and frictional properties of fibrin sealants using an ex vivo model.

Design: Native bovine cartilage-bone composites were assembled with a single application of Tisseel or Vistaseal. Composites were tested in tension and lap shear. In addition, the coefficient of friction (COF) was measured in a native cartilage annulus model alone and with minced cartilage. Finally, the effect of a double application of fibrin sealant was evaluated.

Results: There were no significant differences in tensile modulus, ultimate tensile strength (UTS), shear modulus, or ultimate shear strength (USS) between the 2 fibrin sealants. Both fibrin sealants demonstrated a UTS and USS of <8 and <30 kPa, respectively. There were no differences in COF between the sealants when tested alone or with minced cartilage. A double application of fibrin sealant did not alter the mechanical properties compared with a single application of fibrin sealant.

Conclusions: Fibrin sealant adhesive properties are not affected by the sealant type studied or the number of applications in a bovine cartilage-bone model. Fibrin sealant tribological properties are not affected by sealant type or the addition of minced cartilage. The adhesive properties of Tisseel and Vistaseal were less than those desired for the in vivo fixation of cartilage repair implants. These findings motivate the development of an improved cartilage-specific adhesive for cartilage repair applications.

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用于软骨修复的市售纤维蛋白密封剂的力学评估

目的：纤维蛋白密封剂通常用于软骨碎片和植入物的关节内手术固定。然而，纤维蛋白密封剂在软骨修复中的机械性能尚不清楚。本研究的目的是利用体内外模型鉴定纤维蛋白密封剂的粘附性和摩擦性：设计：使用 Tisseel 或 Vistaseal 一次性粘合剂组装原生牛软骨-骨复合材料。对复合材料进行拉伸和搭接剪切测试。此外，还测量了单独使用和使用碎软骨的原生软骨环模型的摩擦系数（COF）。最后，还评估了双层纤维蛋白密封剂的效果：结果：两种纤维蛋白密封剂在拉伸模量、极限拉伸强度（UTS）、剪切模量或极限剪切强度（USS）方面没有明显差异。结论：在牛软骨模型中，纤维蛋白密封剂的粘合性能不受所研究的密封剂类型或应用次数的影响。纤维蛋白密封剂的摩擦学特性不受密封剂类型或添加碎软骨的影响。Tisseel 和 Vistaseal 的粘合性低于软骨修复植入物体内固定所需的粘合性。这些发现推动了软骨修复应用领域软骨专用粘合剂的开发。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.