Cryptococcal endocarditis of native valve in a patient with systemic lupus erythematosus.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Northern Clinics of Istanbul Pub Date : 2023-04-27 eCollection Date: 2023-01-01 DOI:10.14744/nci.2023.04372
Seyedeh Kimia Yavari, Danielle Lapoint, Amanda Levy, Leili Pourafkari
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引用次数: 0

Abstract

Cryptococcal endocarditis is an exceedingly rare entity associated with high mortality and morbidity. Hereby, we present a 37-year-old patient with underlying systemic lupus erythematosus and end-stage renal disease who was diagnosed with cryptococcal endocarditis involving native mitral valve. Her blood culture grew Cryptococcus neoformans. Echocardiography confirmed presence of vegetations and patient underwent mitral valve replacement and received appropriate anti-fungal treatment. Her course was further complicated by sternal wound dehiscence and infection of hemodialysis site as well as atrial flutter. Unfortunately, patient passed 2 weeks after discharge from hospital. C. neoformans is typically known to cause serious central nervous system. However, this pathogen can rarely cause serious infective endocarditis case particularly in immune compromised patients or those with prosthetic valves. Fungal endocarditis is usually treated with a combination of surgery and anti-fungal medications.

Abstract Image

Abstract Image

一例系统性红斑狼疮患者的天然瓣膜隐球菌性心内膜炎。
隐球菌性心内膜炎是一种极为罕见的高死亡率和高发病率疾病。在此,我们报告了一名37岁的潜在系统性红斑狼疮和终末期肾病患者,他被诊断为隐球菌性心内膜炎,涉及天然二尖瓣。她的血液培养培养培养出了新型隐球菌。超声心动图证实存在赘生物,患者接受了二尖瓣置换术,并接受了适当的抗真菌治疗。胸骨伤口裂开、血液透析部位感染以及心房扑动使她的病程更加复杂。不幸的是,病人出院2周后就去世了。C.新生代通常会引起严重的中枢神经系统。然而,这种病原体很少会引起严重的感染性心内膜炎,尤其是在免疫受损的患者或有人工瓣膜的患者中。真菌性心内膜炎通常采用手术和抗真菌药物相结合的方法治疗。
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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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