Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy.

IF 3 4区医学 Q2 NEUROSCIENCES

Neural Plasticity Pub Date : 2023-01-01 DOI:10.1155/2023/7768980

Yajin Huang, Yaqing Liu, Wenjun Song, Yanjun Liu, Xiaoqian Wang, Juping Han, Jiang Ye, Hongmei Han, Li Wang, Juan Li, Tiancheng Wang

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引用次数: 1

Abstract

Objective: Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy.

Methods: Participants underwent one-night sleep electroencephalogram recording and neuropsychological tests on the same day. Spindle characteristics during N2 sleep were extracted using a learning-based system for sleep staging and an automated spindle detection algorithm. We investigated the difference between cognitive subgroups in spindle characteristics. Multiple linear regressions were applied to analyze associations between cognition and spindle characteristics.

Results: Compared with no/mild cognitive impairment, epilepsy patients who developed severe cognitive impairment had lower sleep spindle density, the differences mainly distributed in central, occipital, parietal, middle temporal, and posterior temporal (P < 0.05), and had relatively long spindle duration in occipital and posterior temporal (P < 0.05). Mini-Mental State Examination (MMSE) was associated with spindle density (pars triangularis of the inferior frontal gyrus (IFGtri): β = 0.253, P = 0.015, and P.adjust = 0.074) and spindle duration (IFGtri: β = -0.262, P = 0.004, and P.adjust = 0.030). Montreal Cognitive Assessment (MoCA) was associated with spindle duration (IFGtri: β = -0.246, P = 0.010, and P.adjust = 0.055). Executive Index Score (MoCA-EIS) was associated with spindle density (IFGtri: β = 0.238, P = 0.019, and P.adjust = 0.087; parietal: β = 0.227, P = 0.017, and P.adjust = 0.082) and spindle duration (parietal: β = -0.230, P = 0.013, and P.adjust = 0.065). Attention Index Score (MoCA-AIS) was associated with spindle duration (IFGtri: β = -0.233, P = 0.017, and P.adjust = 0.081).

Conclusions: The findings suggested that the altered spindle activity in epilepsy with severe cognitive impairment, the associations between the global cognitive status of adult epilepsy and spindle characteristics, and specific cognitive domains may relate to spindle characteristics in particular brain regions.

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成人癫痫患者认知功能与睡眠纺锤体特征的评估。

目的:癫痫可通过干扰睡眠可塑性导致慢性认知功能障碍。睡眠纺锤波在睡眠维持和大脑可塑性中起着至关重要的作用。本研究探讨成人癫痫患者认知与纺锤体特征的关系。方法:对受试者进行夜间睡眠脑电图记录，并于当天进行神经心理测试。采用基于学习的睡眠分期系统和自动纺锤波检测算法提取N2睡眠时的纺锤波特征。我们研究了认知亚组在纺锤体特征上的差异。采用多元线性回归分析认知与纺锤体特征之间的关系。结果:与无/轻度认知障碍的癫痫患者相比，重度认知障碍的癫痫患者睡眠纺锤体密度较低，差异主要分布在中央、枕部、顶叶、颞中部和颞后部(P < 0.05)，枕部和颞后部纺锤体持续时间较长(P < 0.05)。迷你精神状态检查(MMSE)与纺锤体密度(额下回三角部(IFGtri): β = 0.253, P = 0.015, P.adjust = 0.074)和纺锤体持续时间(IFGtri: β = -0.262, P = 0.004, P.adjust = 0.030)相关。蒙特利尔认知评估(MoCA)与纺锤体持续时间相关(IFGtri: β = -0.246, P = 0.010, P.adjust = 0.055)。执行指数评分(MoCA-EIS)与纺锤体密度相关(IFGtri: β = 0.238, P = 0.019, P.adjust = 0.087;顶叶:β = 0.227, P = 0.017, P.adjust = 0.082)和纺锤体持续时间(顶叶:β = -0.230, P = 0.013, P.adjust = 0.065)。注意指数得分(MoCA-AIS)与纺锤波持续时间相关(IFGtri: β = -0.233, P = 0.017, P.adjust = 0.081)。结论:研究结果表明，严重认知障碍癫痫患者的纺锤体活动改变，成人癫痫的整体认知状态与纺锤体特征之间的关联，以及特定的认知领域可能与特定脑区的纺锤体特征有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Plasticity NEUROSCIENCES-

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.