Epigenetic Regulator ASXL2: Structure, Function and its Predictive Value in Diseases.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2023-01-01 DOI:10.2174/1389203724666221208103516

Mengru Li, Lijun Xu, Rui Zhang, Chunming Dong

引用次数: 0

Abstract

ASXL2, as a transcription regulator, is a research hotspot for tumor detection. The aberrant expression of ASXL2 protein has been mainly implicated in malignant hematological and heart diseases. To further explore the predictive value of ASXL2 in diseases, we reviewed the structure and function of ASXL2 protein, the post-translational modification mechanism, and the expression of ASXL2 protein in the pathogenesis of different diseases to provide a theoretical basis and support for the development of future treatments.

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表观遗传调控因子ASXL2:结构、功能及其在疾病中的预测价值

ASXL2作为一种转录调控因子，是肿瘤检测的研究热点。ASXL2蛋白的异常表达主要与恶性血液病和心脏病有关。为了进一步探索ASXL2在疾病中的预测价值，我们综述了ASXL2蛋白的结构和功能、翻译后修饰机制以及ASXL2蛋白的表达在不同疾病发病中的作用，为今后治疗的发展提供理论依据和支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.