Pharmacological Activities and Pharmacokinetics of Glycycoumarin.

IF 1.4 4区医学 Q4 CHEMISTRY, MEDICINAL

Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy Pub Date : 2023-01-01 DOI:10.1007/s43450-022-00342-x

Yumei Tang, Shuiping Ou, Linhu Ye, Sen Wang

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Abstract

Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from Glycyrrhiza uralensis Fisch., Fabaceae. Studies have shown that glycycoumarin has many biological activities, such as anti-tumor, liver protection, antispasmodic, antibacterial, and antivirus. However, the poor solubility of glycycoumarin in water and the accompanying reactions of the phase I (hydroxylation) and II (glucuronidation) metabolism limit its druggability, which manifests as low absorption in the body after oral administration and low free drug concentration, ultimately leading to low bioavailability. Therefore, a comprehensive review of the pharmacological effects and pharmacokinetics of glycycoumarin is presented to provide a reference for further research and application as a therapeutic agent.

Graphical abstract:

Supplementary information: The online version contains supplementary material available at 10.1007/s43450-022-00342-x.

Abstract Image

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甘草香豆素的药理活性及药代动力学研究。

Glycycoumarin是从甘草中分离出来的具有代表性的具有显著药理活性的香豆素类化合物。,蝶形花科。研究表明，甘草香豆素具有抗肿瘤、保肝、抗痉挛、抗菌、抗病毒等多种生物活性。然而，由于糖环香豆素在水中的溶解度较差，以及伴随的I相(羟基化)和II相(葡萄糖醛酸化)代谢反应限制了其可用药性，表现为口服后在体内的吸收率低，游离药物浓度低，最终导致生物利用度低。因此，本文就甘草酸香豆素的药理作用和药代动力学进行综述，为其作为治疗药物的进一步研究和应用提供参考。图片摘要:补充资料:在线版本包含补充资料，下载地址为10.1007/s43450-022-00342-x。

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来源期刊

Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

2.60

自引率

12.50%

发文量

105

审稿时长

3-8 weeks

期刊介绍： The Brazilian Journal of Pharmacognosy is a scientific journal edited and published by the Brazilian Society of Pharmacognosy, an association that brings together researchers, students and professionals who study and investigate the physical, chemical and biological drugs, especially those of vegetable origin, substances isolated and such as the potential source of drugs of natural origin. It is available in printed form for its members and subscribers and openly on the Internet in all your numbers and content. The articles published are original research contributions. To evaluate the work use is made of international standards and is held by the ad hoc advisers, which reflects the quality and credibility of the journal. The BJP is published since 1986.