Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications

Metabolism open Pub Date : 2023-06-01 DOI:10.1016/j.metop.2023.100243

Misganaw Asmamaw Mengstie , Mohammed Abdu Seid , Natnael Atnafu Gebeyehu , Getachew Asmare Adella , Gizchew Ambaw Kassie , Wubet Alebachew Bayih , Molalegn Mesele Gesese , Denekew Tenaw Anley , Sefineh Fenta Feleke , Melkamu Aderajew Zemene , Anteneh Mengist Dessie , Yenealem Solomon , Berihun Bantie , Tadesse Asmamaw Dejenie , Assefa Agegnehu Teshome , Endeshaw Chekol Abebe

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引用次数: 2

Abstract

Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.

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糖尿病肾病中的铁下垂：机制和治疗意义

糖尿病肾病（DN）是糖尿病最常见的并发症，长期以来一直影响着糖尿病患者的生活。大量研究表明脱铁性贫血与肾细胞损伤之间存在牢不可破的联系。脱铁症是一种铁依赖性、非凋亡、受调控的细胞死亡，其特征是细胞内脂质过氧化物积累到致命水平。尽管程序性细胞死亡（如凋亡、自噬和坏死）在DN发病机制中的作用已得到证实，但脱铁性贫血在DN中的意义却很少受到质疑。因此，本综述的主要目的是讨论目前对脱铁性贫血的理解，重点是其潜在机制、与DN的关系以及新出现的治疗机会。

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来源期刊

Metabolism open Agricultural and Biological Sciences (General), Endocrinology, Endocrinology, Diabetes and Metabolism

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审稿时长

40 days