Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions.

IF 5 3区 医学 Q2 IMMUNOLOGY
Yoshiki Omatsu
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引用次数: 0

Abstract

Throughout adult life, most lineages of blood cells, including immune cells, are generated from hematopoietic stem cells (HSCs) in the bone marrow. HSCs are thought to require special microenvironments, termed niches, for their maintenance in the bone marrow; however, the identity of the HSC cellular niche has been a subject of long-standing debate. Although diverse candidates have been proposed so far, accumulated studies demonstrate that the bone marrow-specific population of fibroblastic reticular cells with long processes, termed CXC chemokine ligand 12-abundant reticular cells (which overlap strongly with leptin receptor-expressing cells), termed CAR/LepR+ cells, are the pivotal cellular component of niches for HSCs and lymphoid progenitors. Sinusoidal endothelial cells (ECs) are also important for hematopoietic homeostasis and regeneration. Hematopoiesis is altered dynamically by various stimuli such as inflammation, infection, and leukemia, all of which affect cellular niches and alter their function. Therefore, it is important to consider situations in which stimuli affect HSCs, either via direct interaction or indirectly via the hematopoietic niches. In this review, the dynamics of cellular niches in the steady state and disease are described, with a focus on CAR/LepR+ cells and ECs.

Abstract Image

Abstract Image

正常和恶性情况下骨髓中造血干细胞的细胞壁龛。
在整个成人生活中,大多数血细胞谱系,包括免疫细胞,都是由骨髓中的造血干细胞(hsc)产生的。造血干细胞被认为需要特殊的微环境,称为生态位,以便在骨髓中维持;然而,造血干细胞细胞生态位的身份一直是一个长期争论的主题。尽管到目前为止已经提出了多种候选细胞,但积累的研究表明,具有长过程的成纤维网状细胞的骨髓特异性群体,称为CXC趋化因子配体12丰富的网状细胞(与瘦素受体表达细胞强烈重叠),称为CAR/LepR+细胞,是造血干细胞和淋巴样祖细胞生态位的关键细胞成分。窦状内皮细胞(ECs)对造血稳态和再生也很重要。造血是动态改变的各种刺激,如炎症,感染和白血病,所有这些影响细胞壁龛和改变其功能。因此,重要的是要考虑刺激影响造血干细胞的情况,无论是通过直接相互作用还是间接通过造血生态位。在这篇综述中,描述了细胞生态位在稳态和疾病中的动态,重点是CAR/LepR+细胞和ECs。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
1.20%
发文量
45
审稿时长
11 weeks
期刊介绍: Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.
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