Salvage HDR brachytherapy for prostate cancer: a high-volume center experience on 100 consecutive patients.

IF 1.4 4区医学 Q3 UROLOGY & NEPHROLOGY

Scandinavian Journal of Urology Pub Date : 2023-02-01 DOI:10.1080/21681805.2023.2168048

Lauri Mäkelä, Robin Bergroth, Lauri Taipale, Sara Tornberg, Harri Visapää

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引用次数: 1

Abstract

Aim: This study aims to evaluate the safety and efficacy of salvage HDR brachytherapy in patients who have undergone a thorough diagnostic process.

Materials and methods: 100 prostate cancer patients - locally relapsed after previous radiotherapy - were treated with salvage HDR brachytherapy to a total dose of 24 Gy. Before treatment, the patients underwent PET imaging, prostate MRI, and prostate biopsies to confirm local relapse and exclude systemic disease. Concomitant ADT was applied in 69 patients. Toxicity and efficacy data were collected as a patient chart review. Toxicity was graded using Common Terminology Criteria for Adverse Events (CTCAE 5.0).

Results: The 3-year bDFS and OS were 74% (confidence interval [CI] 95%: 60-87%) and 93% (CI 95%: 84-100%), respectively. Acute Grade 1-2 genitourinary toxicity was observed in 70 patients, 58 patients with Grade 1 and 12 patients with Grade 2, respectively. Acute Grade 1 gastrointestinal toxicity was observed in 8 patients.

Conclusions: This retrospective study shows that salvage HDR brachytherapy is a well-tolerated and effective treatment for histologically proven, local radio-recurrent disease.

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救助性HDR近距离治疗前列腺癌:连续100例患者的高容量中心体验。

目的:本研究旨在评估在经过彻底诊断过程的患者中进行补救性HDR近距离放射治疗的安全性和有效性。材料与方法:对100例既往放疗后局部复发的前列腺癌患者进行补救性HDR近距离放疗，总剂量为24 Gy。治疗前，患者接受PET成像、前列腺MRI和前列腺活检以确认局部复发，排除全身性疾病。同时应用ADT治疗69例。收集毒性和疗效数据作为患者图表回顾。使用不良事件通用术语标准(CTCAE 5.0)对毒性进行分级。结果:3年bDFS和OS分别为74%(置信区间[CI] 95%: 60-87%)和93% (CI 95%: 84-100%)。急性1-2级泌尿生殖系统毒性70例，1级58例，2级12例。8例患者出现急性1级胃肠道毒性。结论:这项回顾性研究表明，对于经组织学证实的局部放射复发性疾病，补救性HDR近距离放疗是一种耐受性良好且有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.90

自引率

6.70%

发文量

期刊介绍： Scandinavian Journal of Urology is a journal for the clinical urologist and publishes papers within all fields in clinical urology. Experimental papers related to clinical questions are also invited.Important reports with great news value are published promptly.