Association Between HOTAIR rs920778 and H19 rs3741219 Polymorphisms with Hashimoto's Thyroiditis (HT) and Graves' Disease (GD).

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2022-10-01 DOI:10.52547/rbmb.11.3.377

Alireza Beiramzadeh, Zahra Heidari, Mahtab Norouzi, Mohsen Saravani

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Abstract

Background Graves' disease (GD) and Hashimoto's thyroiditis (HT) are two autoimmune thyroid diseases (AITDs). The current study aimed to assess possible association between HOTAIR rs920778 and H19 rs3741219 polymorphisms with GD and HT. Methods We recruited 248 patients with autoimmune thyroid disease (133 HT patients and 115 GD patients) and 135 age- and sex-matched controls. The PCR-RFLP method was applied for genotyping of HOTAIR rs920778, and H19 rs3741219 polymorphisms. Results The HOTAIR rs920778 GA frequency was significantly higher in control compared to HT group. The Overdominant model showed a significant association with the risk of HT. However, no significant association was observed between this polymorphism and HT susceptibility in dominant and recessive models. The H19 rs3741219 GA was more repeated in HT patients compared to control group, but the difference was not significant. There was no association between HOTAIR rs920778 and H19 rs3741219 polymorphisms with GD in all genetic models. Discussion Our findings indicated that HOTAIR rs920778 polymorphism decreased the risk of HT. Since, this the first study, further studies with different races are required to confirm our results.

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HOTAIR rs920778和H19 rs3741219多态性与桥本甲状腺炎(HT)和Graves病(GD)的相关性研究

背景:Graves病(GD)和桥本甲状腺炎(HT)是两种自身免疫性甲状腺疾病(AITDs)。本研究旨在评估HOTAIR rs920778和H19 rs3741219多态性与GD和HT之间的可能关联。方法:我们招募了248例自身免疫性甲状腺疾病患者(133例HT患者和115例GD患者)和135例年龄和性别匹配的对照组。采用PCR-RFLP方法对HOTAIR rs920778和H19 rs3741219多态性进行基因分型。结果:与HT组相比，对照组HOTAIR rs920778 GA频率显著升高。Overdominant模型显示与HT风险有显著关联。然而，在显性和隐性模型中，没有观察到这种多态性与HT易感性之间的显著关联。H19 rs3741219基因在HT患者中的重复率高于对照组，但差异无统计学意义。在所有遗传模型中，HOTAIR rs920778和H19 rs3741219多态性与GD均无相关性。讨论:我们的研究结果表明，HOTAIR rs920778多态性降低了HT的风险。由于这是第一次研究，因此需要对不同种族进行进一步的研究来证实我们的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.