Synthesis, structure and biological activity of hydrazones derived from 2- and 4-hydroxybenzoic acid hydrazides

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2023-09-27 DOI:10.1016/j.cdc.2023.101089

Oralgazy A. Nurkenov , Serik D. Fazylov , Zhanarkul B. Satpaeva , Tulegen M. Seilkhanov , Dastan M. Turdybekov , Anel Zh. Mendibayeva , Saule B. Akhmetova , Zarina T. Shulgau , Larisa E. Alkhimova , Ivan V. Kulakov

引用次数: 0

Abstract

The condensation reaction of 4- and 2-hydroxybenzoic acid hydrazides with substituted benzaldehydes led to the formation of a series of hydrazones. The synthesis of hydrazones was carried out successfully in good yields. The structure of compounds was proved by spectral methods. The crystal structures of the methanol solvate of the (E)-N’-[4-(diethylamino)-benzylidene]-4-hydroxybenzohydrazide and the crystalline hydrate of the (E)-N’-[(2‑hydroxy-4-diethylamino)-benzylidene]-4-hydroxybenzohydrazide were described with attention to conformational features and hydrogen bonding. The antimicrobial and antiradical activity of hydrazones was studied using molecular docking and in vitro assays.

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2-羟基苯甲酸和4-羟基苯甲酸腙的合成、结构和生物活性

4-羟基苯甲酸和2-羟基苯甲酸肼与取代苯甲醛发生缩合反应，生成了一系列的腙。成功地合成了腙，产率高。用光谱方法证实了化合物的结构。描述了(E)- n′-[4-(二乙基氨基)-苄基]-4-羟基苯并肼甲醇溶剂化物的晶体结构和(E)- n′-[(2 -羟基-4-二乙基氨基)-苄基]-4-羟基苯并肼的结晶水合物的构象特征和氢键。采用分子对接和体外实验研究了腙的抗菌和抗自由基活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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