Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2022-12-01 DOI:10.1080/13510002.2022.2123864

Jingying Wang, Yinghao Pan, Guangmin Wei, Hanxiao Mao, Rulan Liu, Yuanmin He

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引用次数: 4

Abstract

Objectives: The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis.

Methods: Published papers on vitiligo, oxidative stress and DAMPs were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc.

Results: Oxidative stress may be an important inducer of vitiligo. At high oxidative stress levels, damage-associated molecular patterns (DAMPs) are released from keratinocytes or melanocytes in the skin and induce downstream immune responses during vitiligo. Treatment regimens targeting DAMPs can effectively improve disease severity.

Discussion: DAMPs play key roles in initiating host defenses against danger signals, deteriorating the condition of vitiligo. DAMP levels in serum and skin may be used as biomarkers to indicate vitiligo activity and prognosis. Targeted therapies, incorporating HMGB1, Hsp70, and IL-15 could significantly improve disease etiology. Thus, novel strategies could be identified for vitiligo treatment by targeting DAMPs.

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白癜风损伤相关的分子模式:从氧化应激到黑素细胞损失的引信。

目的:白癜风的发病机制尚不清楚。在这篇综述中，我们全面描述了损伤相关分子模式(DAMPs)在白癜风发病过程中的作用。方法:通过检索PubMed、MEDLINE、Embase等数据库，收集有关白癜风、氧化应激和DAMPs的相关文献，并进行回顾性分析。结果:氧化应激可能是白癜风的重要诱因。在高氧化应激水平下，皮肤中的角质形成细胞或黑素细胞释放损伤相关分子模式(DAMPs)，并在白癜风期间诱导下游免疫反应。针对DAMPs的治疗方案可以有效地改善疾病的严重程度。讨论:DAMPs在启动宿主防御危险信号，恶化白癜风病情方面发挥关键作用。血清和皮肤中的DAMP水平可作为白癜风活动和预后的生物标志物。结合HMGB1、Hsp70和IL-15的靶向治疗可显著改善疾病病因学。因此，可以通过靶向DAMPs来确定白癜风治疗的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.