Evaluation of Simple Markers of Inflammation and Systemic Immune Inflammation Index in Schizophrenia, Bipolar Disorder Patients and Healthy Controls.

IF 0.9 4区医学 Q4 PSYCHIATRY

Turk Psikiyatri Dergisi Pub Date : 2023-01-01 DOI:10.5080/u26248

Ali Inaltekin, İbrahim Yağci

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引用次数: 4

Abstract

Objective: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), mean platelet volume (MPV), and systemic immune inflammation index (SII) are recently used as indicators of inflammation. NLR, PLR, MLR, and MPV have been evaluated in many studies in patients with schizophrenia and bipolar disorder. However, there are no studies investigating SII. This study aims to evaluate NLR, PLR, MLR, MPV and SII values and complete blood count elements in patients hospitalized with diagnoses of the schizophrenia with psychotic episode and bipolar disorder with manic episode by comparing them with the control group.

Method: A total of 149 patients who were hospitalized with the diagnoses of the schizophrenia with psychotic episode and bipolar disorder with manic episode and who met the inclusion criteria were included in our study where the control group was composed of 66 healthy individuals. White blood cell (WBC), neutrophil, lymphocyte, platelet, and monocyte counts were obtained retrospectively from complete blood counts at the time of admission, based on which NLR, PLR, MLR, and SII were calculated.

Results: In this study, higher NLR, PLR, and SII values and lower MPV and lymphocyte counts were observed in schizophrenia patients compared to the control group. NLR, PLR, and SII values and neutrophil counts were higher in patients with bipolar disorder compared to the control group. Lower MPV values were found in patients with schizophrenia compared to patients with bipolar disorder.

Conclusion: Simple inflammatory and SII values in our study indicate the presence of low-grade systemic inflammation in schizophrenia and bipolar disorder.

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精神分裂症、双相情感障碍患者和健康对照的炎症简单标志物和系统免疫炎症指数的评估。

目的：中性粒细胞淋巴细胞比率（NLR）、血小板淋巴细胞比率（PLR）、单核细胞-淋巴细胞比率（MLR）、平均血小板体积（MPV）和全身免疫炎症指数（SII）最近被用作炎症的指标。NLR、PLR、MLR和MPV已在许多精神分裂症和双相情感障碍患者的研究中进行了评估。然而，没有研究调查SII。本研究旨在通过与对照组的比较，评估诊断为精神分裂症伴精神病发作和双相情感障碍伴躁狂发作的住院患者的NLR、PLR、MLR、MPV和SII值以及全血细胞计数元素。方法：将149名诊断为精神分裂症伴精神病发作和双相情感障碍伴躁狂发作并符合纳入标准的患者纳入我们的研究，其中对照组由66名健康人组成。从入院时的全血计数中回顾性获得白细胞（WBC）、中性粒细胞、淋巴细胞、血小板和单核细胞计数，在此基础上计算NLR、PLR、MLR和SII。结果：在本研究中，与对照组相比，精神分裂症患者的NLR、PLR和SII值较高，MPV和淋巴细胞计数较低。与对照组相比，双相情感障碍患者的NLR、PLR和SII值以及中性粒细胞计数较高。与双相情感障碍患者相比，精神分裂症患者的MPV值较低。结论：我们研究中的单纯炎症和SII值表明精神分裂症和双相情感障碍存在低度全身炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turk Psikiyatri Dergisi PSYCHIATRY-

CiteScore

1.30

自引率

11.10%

发文量