Endogenous antioxidant level of stem cell is important for the transplantation efficacy

Abstract

Stem cell transplantation has been applied to clinical trials and obtained certain curative effect, but due to the severe environmental such as oxidative stress, the efficiency of stem cell transplantation is still low. However, oxidative stress on stem cells, the influence of the transplantation efficiency and its molecular mechanism are not fully understood. In our recent research, we have confirmed that oxidative stress is the mainly reason that caused the low efficiency of hUCMSCs transplantation. In vitro, antioxidants pretreatment of the hUCMSCs can decrease cell apoptosis through the MAPK-PKC-Nrf2 pathway. In vivo, antioxidants pretreatment can accelerate the host hepatic regenerative process and improve the expansion efficiency of stem cells. In this research, the antioxidant we used is edaravone which is now widely used in clinic. Thus, our study has answered how the oxidative stress affects stem cell transplantation efficiency and puts forward a clinical antioxidant which can improve the endogenous antioxidant level of stem cells.