PRION 2019 emerging concepts

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-05-15 DOI:10.1080/19336896.2019.1615197

Meyer-Luehmann, C. Sigurdson, M. Jucker

引用次数: 2

Abstract

The presentation will summarize the results of various studies conducted at our research center that assess the transmissibility of the chronic wasting disease (CWD) agent to cattle, pigs, raccoons, goats, and sheep. This will include specifics of the relative attack rates, clinical signs, and microscopic lesions with emphasis on how to differentiate cross-species transmission of the CWD agent from the prion diseases that naturally occur in hosts such as cattle or sheep. Briefly, the relative difficulty of transmitting the CWD agent to sheep and goats will be contrasted with the relative ease of transmitting the scrapie agent to white-tailed deer. 2. RT-QuIC seed amplification assays in the diagnosis of prion diseases, synucleinopathies and tauopathies

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朊病毒2019新兴概念

本报告将总结我们研究中心进行的各种研究的结果，这些研究评估了慢性消耗性疾病(CWD)病原体对牛、猪、浣熊、山羊和绵羊的传播性。这将包括相对发病率、临床症状和显微镜下病变的具体情况，重点是如何区分CWD病原体的跨物种传播与自然发生在牛或羊等宿主中的朊病毒疾病。简单地说，将CWD媒介传播给绵羊和山羊的相对困难与痒病媒介传播给白尾鹿的相对容易进行对比。2. RT-QuIC种子扩增检测在朊病毒病、突触核蛋白病和牛头病诊断中的应用

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.