Metal Complexes of Gatifloxacin: Synthesis, Characterization and Evaluation of Biological Activity

Abstract

The antibiotic agent Gatifloxacin is well known for its drug design and coordinating ability towards metal ions. In this paper, synthesis and biological activity of Mn(II), Co(II), Ni(II), Cu(II) and Mg(II) complexes of gatifloxacin is reported. Ligand is itself prepared using o-phenylenediamine (OPD) and 3-acetyl coumarin. The structure of complexes has been investigated using some physiochemical and spectroscopic techniques. In vitro evaluation of these complexes was also carried out for antibacterial and antimicrobial activity. Some complexes exhibited promising anti-bacterial and antimicrobial activity compared to gatifloxacin drug.