Wnt signalling in the articular cartilage: A matter of balance

IF 1.8 4区医学 Q3 PATHOLOGY

International Journal of Experimental Pathology Pub Date : 2023-02-26 DOI:10.1111/iep.12472

Amandeep Kaur Gill, Peter J. McCormick, David Sochart, Giovanna Nalesso

引用次数: 1

Abstract

Degradation of the articular cartilage is a hallmark of osteoarthritis, a progressive and chronic musculoskeletal condition, affecting millions of people worldwide. The activation of several signalling cascades is altered during disease development: among them, the Wnt signalling plays a pivotal role in the maintenance of tissue homeostasis. Increasing evidence is showing that its activation needs to be maintained within a certain range to avoid the triggering of degenerative mechanisms. In this review, we summarise our current knowledge about how a balanced activation of the Wnt signalling is maintained in the articular cartilage, with a particular focus on receptor-mediated mechanisms.

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关节软骨中的Wnt信号:一个平衡问题

关节软骨退化是骨关节炎的标志，骨关节炎是一种进行性和慢性肌肉骨骼疾病，影响着全世界数百万人。几种信号级联的激活在疾病发展过程中发生改变:其中，Wnt信号在维持组织稳态中起关键作用。越来越多的证据表明，它的激活需要保持在一定的范围内，以避免触发退行性机制。在这篇综述中，我们总结了目前关于Wnt信号如何在关节软骨中维持平衡激活的知识，并特别关注受体介导的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Experimental Pathology 医学-病理学

CiteScore

4.50

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes. The International Journal of Experimental Pathology - IJEP - publishes papers which afford new and imaginative insights into the basic mechanisms underlying human disease, including in vitro work, animal models, and clinical research. Aiming to report on work that addresses the common theme of mechanism at a cellular and molecular level, IJEP publishes both original experimental investigations and review articles. Recent themes for review series have covered topics as diverse as "Viruses and Cancer", "Granulomatous Diseases", "Stem cells" and "Cardiovascular Pathology".