Effect of silyl group of methacrylate copolymer on its biocompatibility and ability to give a corrosion resistance to magnesium alloy

Abstract

Magnesium alloys have recently been expected as a main material for a bioresorbable vascular stent. However, the alloys have a major defect, a very poor corrosion resistance under the wet circumstance such as a body. One of the methods to give the corrosion resistance to the Mg alloys, polymer coating has been investigated. From these back grounds, we designed a new coating polymer, poly(2-methoxyethyl methacrylate  ran  trimethoxysilylplopyl methacrylate), and investigated the effect of silyl group on their biocompatibility and ability to give a corrosion resistance to the alloy. The polymer showed good compatibility with platelets and coagulation system and improved the corrosion resistance in the cell culture medium as a simulated