Synthesis and characterization of levan hydrogels and their use for resveratrol release

IF 2.1 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Bioactive and Compatible Polymers Pub Date : 2021-10-29 DOI:10.1177/08839115211055725

S. S. Selvi̇, Merve Erginer Hasköylü, Seval Genç, Ebru Toksoy Öner

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引用次数: 8

Abstract

Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized and then cross-linked with 1,4-Butanediol diglycidyl ether (BDDE) and the obtained hydrogels were characterized in terms of their swelling, adhesivity, and rheological properties. Both native and phosphonated HL hydrogels retained their rigid gel like structure with increasing shear stress levels and tack test analysis showed superior adhesive properties of the phosphonated HL hydrogels. Moreover, hydrogels were loaded with resveratrol and entrapment and release studies as well as cell culture studies with human keratinocytes were performed. Biocompatible and adhesive features of the hydrogels confirmed their suitability for tissue engineering and drug delivery applications.

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利凡水凝胶的合成、表征及其在白藜芦醇释放中的应用

考虑到利凡酸盐单胞菌(Halomonas levan, HL)及其化学衍生物的水凝胶的合成、综合表征及其释药性能，需要对其进行系统的研究，以扩大其在药物传递系统和生物医学领域的应用。为此，化学合成了水解和膦化的HL衍生物，然后与1,4-丁二醇二缩水甘油醚(BDDE)交联，并对所得到的水凝胶进行了溶胀性、黏附性和流变性能的表征。随着剪切应力水平的增加，天然和磷酸盐化的HL水凝胶都保持了其刚性的凝胶状结构，粘性测试分析表明，磷酸盐化的HL水凝胶具有更好的粘附性能。此外，水凝胶装载白藜芦醇，并进行了包裹和释放研究以及人类角质形成细胞的细胞培养研究。水凝胶的生物相容性和粘附特性证实了它们在组织工程和药物输送应用中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioactive and Compatible Polymers 工程技术-材料科学：生物材料

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).