Cytogenetic Evaluation of Couples With Spontaneous Abortion, Still Birth and Recurrent Miscarriage in Qazvin: Report and Review

Biotechnology and Health Sciences Pub Date : 2016-03-05 DOI:10.17795/BHS-35388

R. Najafipour, J. Ansari, Manijeh Jalilvand, S. Moghbelinejad

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引用次数: 2

Abstract

Background: Chromosomal abnormality plays an important role in different types of miscarriages. Objectives: The present study was designed to investigation chromosomal anomalies in three groups of couples with recurrent abortion (RA), spontaneous abortion (SA) and still birth (SB). PatientsandMethods: In this retrospective study, the frequency of chromosomal aberrations was investigatedamong 260 couples with miscarriage, which had referred to the cytogenetic section of a reference laboratory in Buali hospilal, Qazvin, Iran from 2009 to 2014. Metaphase spreads were analyzed using G-banding. Results: In this study, 7.6% of couples had chromosomal aberrations including, balanced reciprocal translocations, robertsonian translocations, inversions and sex chromosome aneuploidy. Frequency of balanced translocations was higher, specifically in couples with SA. Conclusions: In this investigation we showed that chromosomal abnormalities could be one of the important causes of miscarriages. Cytogenetic evaluation of couples, which experienced different types of miscarriage, may prevent unnecessary treatments. Keywords: Recurrent Abortion, Spontaneous Abortion, Still Birth, Chromosome Abnormality

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卡兹温地区自然流产、死产和复发性流产夫妇的细胞遗传学评价:报道与回顾

背景:染色体异常在不同类型的流产中起重要作用。目的:探讨三组反复流产(RA)、自然流产(SA)和死胎(SB)夫妇的染色体异常情况。患者和方法:回顾性分析2009 - 2014年在伊朗加兹温Buali医院参考实验室细胞遗传学部门查询的260对流产夫妇染色体畸变频率。采用g带分析中期扩散。结果:本研究中，7.6%的夫妻存在染色体畸变，包括平衡易位、罗伯逊易位、倒位和性染色体非整倍体。平衡易位的频率更高，特别是在SA夫妇中。结论:本研究显示染色体异常可能是流产的重要原因之一。对经历过不同类型流产的夫妇进行细胞遗传学评估，可以防止不必要的治疗。关键词:反复流产，自然流产，死产，染色体异常

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Biotechnology and Health Sciences

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