The Effects of Cannabidiol on Canine Epilepsy and Arthritis – a Case Study

Andra Popescu, Debra Rebeca Băzărea, A. Dreanca, O. Sárpataki, B. Sevastre, I. Marcus
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Abstract

Cannabidiol oil (CBD) has gained notoriety in recent years due to its effectiveness as an adjuvant therapy in many pathologies.The purpose of this study is to evaluate the effects of CBD in the management of pain and the associated pathologies of epilepsy and arthritis, on a single subject, a female Labrador, 12.5 years old at the beginning of the study. The therapeutic protocol used was the administration of CBD oil, sublingually, in doses of 2.25 mg/kg/day. Hematology and biochemistry were performed at 3, 6 and 12 months. Radiology was performed before the study began and after 6 months.After the first month, a decrease in the number and severity of epilepsy crises was observed. Beginning with the first 2 weeks of CBD oil administration, the patient was already experiencing an improvement in her mobility along with general pain remittance and the amelioration of her 3rd degree lameness, quantified by the Colorado Pain Scale. After 5 months of CBD administration, with no seizures recorded, phenytoin therapy was ceased. After 8 months, phenobarbital was also excluded from the therapeutic protocol, thus making CBD an independent the rapeutic molecule. CBD appears to be a useful molecule in managing both pain and epilepsy.
大麻二酚对犬癫痫和关节炎的影响-一个案例研究
近年来,大麻二酚油(CBD)因其在许多疾病中作为辅助治疗的有效性而声名狼藉。本研究的目的是评估CBD在治疗疼痛以及癫痫和关节炎相关病理方面的作用,研究对象是一只12.5岁的雌性拉布拉多犬。使用的治疗方案是舌下给药CBD油,剂量为2.25 mg/kg/天。分别于3、6、12个月进行血液学和生化检查。在研究开始前和6个月后分别进行放射学检查。第一个月后,观察到癫痫发作的次数和严重程度有所下降。从使用CBD油的前2周开始,患者的活动能力已经得到改善,疼痛减轻,三度跛行也得到改善,通过Colorado疼痛量表进行量化。施用CBD 5个月后,无癫痫发作记录,苯妥英治疗停止。8个月后,苯巴比妥也被排除在治疗方案之外,从而使CBD成为独立的治疗分子。CBD似乎是治疗疼痛和癫痫的有效分子。
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12
审稿时长
4 weeks
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