Rutin: A Potential Therapeutic Agent for Alzheimer Disease

Abstract

Xu et al. reported that rutin decreases β-amyloid plaque aggregation, nitric oxide production, the pro-inflammatory cytokines, cytotoxicity and oxidative stress in-vitro. They additionally investigated its in-vivo neuroprotective effects on alzheimer-diseased transgenic mice, where they reported an attenuation of the memory deficits, increase of antioxidant parameters as reduced glutathione and super oxide dismutase, decrease in lipid peroxidation levels, as indicated by malondialdehyde, as well as decreased brain interleukin-1β and interleukin-6 levels [2].