Titanium-nanohydroxyapatite composites produced by ball milling and sintering: wettability, bioactivity and toxicity studies

IF 0.9 4区材料科学 Q3 METALLURGY & METALLURGICAL ENGINEERING

Metallurgical Research & Technology Pub Date : 2022-01-01 DOI:10.1051/metal/2022005

E. Krishna, G. Suresh

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引用次数: 1

Abstract

In the present work, nano-hydroxyapatite (HA) was used as dispersing phase to develop Ti based composites. The mixture of powders with 5% and 10% HA and remaining being Ti were ball milled for 20 h. The ball milled powders were characterized by X-Ray diffraction analysis, electron microscopy. The powders were then sintered at 850 °C in vacuum. Higher surface energies were observed for the composites compared with medical grade purer Ti calculated from the water contact angles. This can be attributed to the smaller grain size and the presence of nano-HA in the composites. Immersion studies carried out in simulated body fluid for 4 weeks demonstrated excellent bioactivity for the composite as reflected from the higher mineral deposition from the SBF. This can be explained by considering the effect of higher wettability and added nano-HA in the composites. All the samples were found to be nontoxic against 3T3 cells as observed from the cytotoxicity test using MTT assay. Hence, from the results, it can be understood that bioactive Ti-HA composites can be produced from ball milling and sintering which exhibit excellent bioactivity to promote higher healing rate.

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球磨和烧结制备的钛-纳米羟基磷灰石复合材料:润湿性、生物活性和毒性研究

本研究以纳米羟基磷灰石(HA)为分散相制备钛基复合材料。将含5%和10%透明质酸的粉末与剩余的Ti混合球磨20 h。采用x射线衍射分析、电子显微镜对球磨粉末进行了表征。然后在850°C真空中烧结粉末。与从水接触角计算的医用级纯钛相比，复合材料的表面能更高。这可以归因于较小的晶粒尺寸和纳米ha在复合材料中的存在。在模拟体液中浸泡4周的研究表明，从SBF中较高的矿物质沉积可以看出，该复合材料具有出色的生物活性。这可以通过在复合材料中添加更高的润湿性和纳米ha来解释。MTT法细胞毒性试验发现，所有样品对3T3细胞均无毒。由此可见，采用球磨和烧结法制备生物活性Ti-HA复合材料具有良好的生物活性，可促进较高的愈合率。

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来源期刊

Metallurgical Research & Technology METALLURGY & METALLURGICAL ENGINEERING-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

4.4 months

期刊介绍： Metallurgical Research and Technology (MRT) is a peer-reviewed bi-monthly journal publishing original high-quality research papers in areas ranging from process metallurgy to metal product properties and applications of ferrous and non-ferrous metals and alloys, including light-metals. It covers also the materials involved in the metal processing as ores, refractories and slags. The journal is listed in the citation index Web of Science and has an Impact Factor. It is highly concerned by the technological innovation as a support of the metallurgical industry at a time when it has to tackle severe challenges like energy, raw materials, sustainability, environment... Strengthening and enhancing the dialogue between science and industry is at the heart of the scope of MRT. This is why it welcomes manuscripts focusing on industrial practice, as well as basic metallurgical knowledge or review articles.