An uncommon case of placental histopathology with antenatal fetal death under new coronavirus infection

A. E. Kasparova, E. D. Khadieva, E. I. Kutefa, V. L. Yanin, E. N. Vasil'kovskaya, L. Chegus, N. A. Sazonova, F. R. Khidirnebieva
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Abstract

   Since the beginning of the COVID-19 pandemic, there have been a number of studies related to the impact of SARS-CoV-2 on the course of pregnancy and fetus condition. As observed, the placentas of women who have had a new coronavirus infection often contain more villous agglutination and subchorionic thrombi than placentas in SARS-CoV-2-negative women. To date, several isolated publications have reported clinical cases of fetal death in mothers infected with coronavirus infection. The authors have made an assumption on the association of adverse outcomes with placental lesions.   The aim of the study was to analyse a clinical case of a moderate-course new coronavirus infection in a pregnant woman at a long gestation period who underwent an antenatal fetal death, and evaluate the features of placental histopathology and their impact on adverse gestational outcomes.   Material and methods. The authors have analysed Russian and international research publications from various sources, including eLIBRARY.RU, CyberLeninka, PubMed databases etc. and, considering the data obtained, investigated a clinical case of intrauterine fetal death in a pregnant woman infected with SARS-CoV-2. The placenta was studied in accordance with the clinical recommendations of the Russian Society of Pathologists "Rules for placental pathological and anatomical examination" and the international classification of placental lesions (Amsterdam, 2015).   Results. The results obtained support the association between acute diseases of the upper respiratory tract and developing severe hemodynamic disorders in the "mother-placenta-fetus" system in pregnant women infected with SARS-CoV-2. Systemic inflammation associated with new coronavirus infection appears to be one of the mechanisms for developing placental disorders.
新型冠状病毒感染导致胎儿死亡的罕见胎盘组织病理学报告1例
自COVID-19大流行开始以来,已有多项研究与SARS-CoV-2对妊娠过程和胎儿状况的影响有关。据观察,新冠病毒感染妇女的胎盘通常比sars - cov -2阴性妇女的胎盘含有更多的绒毛凝集和绒毛膜下血栓。迄今为止,一些孤立的出版物报道了感染冠状病毒的母亲胎儿死亡的临床病例。作者已经作出了一个与胎盘病变不良后果的关联假设。本研究的目的是分析1例中程新型冠状病毒感染的长妊娠期孕妇产前死胎的临床病例,并评估胎盘组织病理学特征及其对妊娠不良结局的影响。材料和方法。作者分析了来自包括图书馆在内的各种来源的俄罗斯和国际研究出版物。RU、CyberLeninka、PubMed等数据库,结合获得的资料,对1例感染SARS-CoV-2孕妇宫内胎儿死亡的临床病例进行调查。根据俄罗斯病理学家协会“胎盘病理和解剖检查规则”的临床建议和胎盘病变的国际分类(阿姆斯特丹,2015)对胎盘进行研究。结果。本研究结果支持了急性上呼吸道疾病与感染SARS-CoV-2的孕妇“母亲-胎盘-胎儿”系统发生严重血流动力学障碍之间的关联。与新型冠状病毒感染相关的全身性炎症似乎是发生胎盘疾病的机制之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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