Active glottal closure during anoxic gasping in lambs

François Thuot , David Lemaire , Dominique Dorion , Patrick Létourneau , Jean-Paul Praud
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引用次数: 25

Abstract

The present study was aimed at assessing laryngeal dynamics and their consequences during anoxic gasping in ketamine-sedated lambs. We first verified that the glottis was closed between gasps during anoxic gasping in seven chronically instrumented lambs, aged 11–15 days. Recording of glottal constrictor muscle electrical activity, subglottal pressure and lung volume, together with endoscopic observation, confirmed the presence of active glottal closure with maintenance of a high lung volume between gasps. Secondly, we tested whether maintenance of a high lung volume between gasps improved autoresuscitation efficiency. Six sedated lambs aged 8–11 days underwent two anoxic runs, including one with an open tracheostomy to prevent maintenance of a high lung volume. Access back to air was allowed for gasping. No significant difference was found in time to eupnea resumption, hemodynamic parameters or arterial blood gases. We conclude that a high lung volume is actively maintained by glottal closure between anoxic gasps in sedated lambs. Further studies are however needed to define the importance of laryngeal dynamics during gasping.

羔羊缺氧喘气时的主动声门关闭
本研究旨在评估氯胺酮镇静的羔羊在缺氧喘气过程中的喉动力学及其后果。我们首先证实了7只11-15天龄长期使用仪器的羔羊在缺氧喘气期间声门关闭。记录声门收缩肌电活动、声门下压力和肺容量,并结合内窥镜观察,证实声门主动关闭的存在,并在喘息之间保持高肺容量。其次,我们测试了在两次喘息之间维持高肺容量是否能提高自动复苏效率。6只8-11天大的镇静羔羊进行了两次缺氧试验,其中一只进行了气管切开手术,以防止维持高肺容量。喘气时可以回到空气中。两组患者在呼吸恢复时间、血流动力学参数和动脉血气方面均无显著差异。我们得出结论,在镇静的羔羊缺氧喘息期间,高肺容量是通过声门关闭积极维持的。然而,需要进一步的研究来确定喘气过程中喉动力学的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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