Evaluation of Serum Levels of Vitamin D in Patients with Vitiligo: A Case-Control Study

Farnaz Soltani, Esmaeil Rezazadeh Bazaz, F. Mashhadi, Mohammad Taha Saadati Rad, Hannah Humphries, Z. Ghaffari, M. Ayyasi
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Abstract

Introduction: Vitiligo is an autoimmune disease that is caused by the destruction of melanocytes and is appeared as depigmented patches on skin and mucosa. There have been various reports of serum Vitamin D levels in patients with vitiligo. The present study aimed to Evaluation of serum Vitamin D levels in patients with vitiligo. Material and Methods: A case-control study was performed on 138 samples among people referring to Sabzevar Vasei clinic in the period of 2018-2019. The research units meeting the inclusion criteria were selected using convenience sampling and then divided into two group case and control (69 patients and 69 healthy people). After obtaining informed consent and completing the checklist of demographic characteristics, blood samples were taken from both groups and serum levels of Vitamin D in both groups were evaluated and compared. Data were analyzed using SPSS 20 via the independent t-test, chi-square test, Mann-Whitney test, Spearman correlation at a significance level of less than 0.01. Results: In total, 131 participants completed the study; the two groups did not differ significantly in terms of age nor gender. At the end of the study, the mean of serum levels of Vitamin D in was significantly lower in the patients with vitiligo than in the people without vitiligo (P <0.001). Conclusion: The results showed that serum Vitamin D levels in patients with vitiligo are lower than in those who do not have vitiligo. Therefore, it is recommended to measure the serum level of Vitamin D in these patients and if it is low, a treatment regimen should begin for these patients.
白癜风患者血清维生素D水平的评估:一项病例对照研究
简介:白癜风是一种由黑色素细胞破坏引起的自身免疫性疾病,在皮肤和粘膜上表现为色素沉着斑块。关于白癜风患者血清维生素D水平的报道有很多。本研究旨在评估白癜风患者血清维生素D水平。材料与方法:对2018-2019年在Sabzevar Vasei诊所就诊的138例患者进行病例对照研究。采用方便抽样的方法选择符合纳入标准的研究单位,分为两组病例和对照组(69例患者和69例健康人)。在获得知情同意并完成人口统计学特征清单后,从两组中抽取血液样本,并对两组的血清维生素D水平进行评估和比较。数据采用SPSS 20进行分析,采用独立t检验、卡方检验、Mann-Whitney检验,Spearman相关性在显著性水平< 0.01。结果:共有131名参与者完成了研究;两组在年龄和性别方面没有显著差异。研究结束时,白癜风患者血清中维生素D的平均水平明显低于非白癜风患者(P <0.001)。结论:白癜风患者血清维生素D水平明显低于非白癜风患者。因此,建议测量这些患者的血清维生素D水平,如果低,则应开始治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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