Nutrient and Anti-diabetic Activity of Azadirecta indica and Corriandrum sativum Leaf Extract on Allaxon Induced Diabetic Rat

S. Pandey, Vijay Chandra Verma, K. Srivastava, R. Yadav
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Abstract

Azadirecta indica (Meliaceae) is a medicinal plant, commonly known as ‘Neem’ and distributed randomly in the whole of India. Corriandrum sativum belongs to the family of Apiaceae was considered to be native from Asia and Africa and known locally in Sudan as Kazbra. Azadirecta indica and Corriandrum sativum extract have been studied for therapeutic possessions. The nutrient parameters and gas chromatography mass spectroscopy (GC-MS) analysis in the leaves of Azadirecta indica and Corriandrum sativum were studied and also the antihyperglycemic activity of hydro alcoholic extract. An acute oral toxicity study was carried out in healthy male Wister rats (100 g). Diabetic rats were orally and daily administrated of hydro alcoholic leaf extract of A. indica and C. sativum at the different doses (200-400 mg/kg. b.w) with anti-diabetic reference drug (metformin). After 21st days of treatment, level of blood glucose, as well as Albumin, Protein, Creatinine, Urea and Uric acid were significantly decreased when compared with the diabetic control. These plant fruit extract will be subjected for further extensive studies to isolate and identify their active constituents which are useful for against antidiabetic. Ethanol leaf extract of Azadirecta indica effect was confirmed minerals such as sodium (Na), copper (Cu), magnesium (Mg), manganese (Mn), Cobalt (Co) and iorn (Fe) were decreases of the respect of Corriandrum sativum. The results was indicated that the hydro alcoholic extract from leaves of Azadirecta indica and Corriandrum sativum showed the reduced blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Azadirecta indica and Corriandrum sativum leaf compared to diabetic control rats. These observed strongly suggest that hydro alcoholic extract could act as a source of functional compounds for the control of diabetes mellitus.
杜鹃花和芫荽叶提取物对Allaxon诱导的糖尿病大鼠的营养和抗糖尿病活性
Azadirecta indica(楝科)是一种药用植物,通常被称为“楝树”,在整个印度随机分布。Corriandrum sativum属于Apiaceae科,被认为原产于亚洲和非洲,在苏丹当地被称为Kazbra。研究了azazdirecta indica和corandrum satium提取物的治疗作用。研究了杜鹃花和芫荽叶的营养参数、气相色谱-质谱(GC-MS)分析以及水乙醇提取物的降糖活性。对健康雄性Wister大鼠(100 g)进行急性口服毒性研究。以不同剂量(200-400 mg/kg)给药给糖尿病大鼠。B.w .)与抗糖尿病参考药物(二甲双胍)。治疗21 d后,血糖、白蛋白、蛋白、肌酐、尿素、尿酸水平均较糖尿病对照组显著降低。这些植物果实提取物将进行进一步的研究,以分离和鉴定其抗糖尿病的有效成分。证实了杜鹃花叶片乙醇提取物的效果,其中钠(Na)、铜(Cu)、镁(Mg)、锰(Mn)、钴(Co)和铁(Fe)等矿物质含量降低。结果表明,两种剂量的杜鹃花和芫荽叶乙醇提取物对糖尿病大鼠的血糖及其他生化指标的影响均低于糖尿病对照组大鼠。这些观察结果强烈提示水乙醇提取物可作为控制糖尿病的功能化合物的来源。
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