Effect of Artesunate on Haematological and Plasma Biochemical Parameters in Female Wistar Rats

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-06-30 DOI:10.13005/bpj/2706

Oyedeji K. O, Abiodun A

引用次数: 0

Abstract

This study was designed to investigate effect of artesunate on blood parameters in female rats. Ten female Wistar rats (130 – 150 g) were grouped into control and artesunate (1.43 mg/kg) – treated groups for blood assay. The artesunate was administered orally for 50 days. Hematological assay was carried out using hemocytometer, while biochemical assay was carried out using spectrophotometry. Mean +/- SEM and student’s t-test at p<0.05 were determined. Artesunate (1.43 mg/kg) significantly reduced RBC, platelet and lymphocyte counts when compared to their controls. It also significantly decreased total protein, ALT and ALP values relative to their controls. However, it induced no significant changes in the PCV, Hb, TWBC, neutrophil, monocyte, eosinophil, MCV, MCHC, MCH, albumin, globulin, AST, BUN and creatinine values relative to their controls. Conclusively, it can be suggested that artesunate had both harmful and advantageous effects on blood parameters in female rats.

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青蒿琥酯对雌性Wistar大鼠血液学及血浆生化指标的影响

本研究旨在探讨青蒿琥酯对雌性大鼠血液指标的影响。将雌性Wistar大鼠10只(130 ~ 150 g)分为对照组和青蒿琥酯(1.43 mg/kg)处理组进行血液测定。口服青蒿琥酯50天。血液学测定采用血细胞计，生化测定采用分光光度法。均数+/- SEM和学生t检验p<0.05。与对照组相比，青蒿琥酯(1.43 mg/kg)显著降低了红细胞、血小板和淋巴细胞计数。与对照组相比，总蛋白、ALT和ALP值也显著降低。然而，与对照组相比，PCV、Hb、TWBC、中性粒细胞、单核细胞、嗜酸性粒细胞、MCV、MCHC、MCH、白蛋白、球蛋白、AST、BUN和肌酐值没有显著变化。综上所述，青蒿琥酯对雌性大鼠的血液参数既有有益的影响，也有有害的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

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