Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, anin vivotool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction
A. Buckl, E. Quintana, Grace J. Lee, N. Shifrin, Mengqi Zhong, L. Garrenton, David C. Montgomery, Carlos Stahlhut, F. Zhao, D. Whalen, Severin Thompson, Arlyn Tambo-ong, Micah J. Gliedt, J. Knox, Cregg James Joseph, N. Aay, Jong Choi, Bao Nguyen, Atti Tripathi, Ruiping Zhao, Mae Saldajeno-Concar, Abby Marquez, Daphne Hsieh, Laura L. McDowell, E. Koltun, Alun Bermingham, D. Wildes, Mallika Singh, Zhengping Wang, R. Hansen, Jan Smith, A. Gill
{"title":"Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, anin vivotool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction","authors":"A. Buckl, E. Quintana, Grace J. Lee, N. Shifrin, Mengqi Zhong, L. Garrenton, David C. Montgomery, Carlos Stahlhut, F. Zhao, D. Whalen, Severin Thompson, Arlyn Tambo-ong, Micah J. Gliedt, J. Knox, Cregg James Joseph, N. Aay, Jong Choi, Bao Nguyen, Atti Tripathi, Ruiping Zhao, Mae Saldajeno-Concar, Abby Marquez, Daphne Hsieh, Laura L. McDowell, E. Koltun, Alun Bermingham, D. Wildes, Mallika Singh, Zhengping Wang, R. Hansen, Jan Smith, A. Gill","doi":"10.1158/1538-7445.AM2021-1273","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":12258,"journal":{"name":"Experimental and Molecular Therapeutics","volume":"44 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and Molecular Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/1538-7445.AM2021-1273","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}