Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, anin vivotool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction
A. Buckl, E. Quintana, Grace J. Lee, N. Shifrin, Mengqi Zhong, L. Garrenton, David C. Montgomery, Carlos Stahlhut, F. Zhao, D. Whalen, Severin Thompson, Arlyn Tambo-ong, Micah J. Gliedt, J. Knox, Cregg James Joseph, N. Aay, Jong Choi, Bao Nguyen, Atti Tripathi, Ruiping Zhao, Mae Saldajeno-Concar, Abby Marquez, Daphne Hsieh, Laura L. McDowell, E. Koltun, Alun Bermingham, D. Wildes, Mallika Singh, Zhengping Wang, R. Hansen, Jan Smith, A. Gill
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