The stratum corneum barrier – From molecular scale to macroscopic properties

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science Pub Date : 2023-10-01 DOI:10.1016/j.cocis.2023.101725

Emma Sparr , Sebastian Björklund , Q. Dat Pham , Enamul H. Mojumdar , B. Stenqvist , M. Gunnarsson , D. Topgaard

引用次数: 1

Abstract

The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.

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角质层屏障——从分子尺度到宏观性质

我们皮肤的上层，角质层(SC)，是一种多功能材料，结合了机械强度和有效的屏障功能。在本文中，我们讨论了这些宏观性质的SC的分子反应和结构多样性的SC蛋白和脂质的最新发现。我们特别关注中间(胶体)长度尺度，以及不同的SC亚结构如何相互组织，包括皮肤中非平衡条件对水和其他成分梯度的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.