CALCIUM DEFICIENCY CORRECTION IN TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH ESSENTIAL HYPERTENSION

Abstract

It has been analysed the influence of calcium deficiency correction on chronic obstructive pulmonary disease in combination with essential hypertension course in 60 patients. We estimated calcium deficiency by peroral calcium-tolerative test with taking of 0,25 mmol/kg body weight calcium gluconate by decrease of loading calciemia elimination speed during 240 min, endothelial dysfunction by brachial artery dilation in reactive hyperemia, daily blood pressure (BP) monitoring, functional pulmonary capacity, intensity of calcium transport between the extracellular fluid and the bone compare to results of examination of 30 healthy persons and 30 patients with essential hypertension. After course of treatment with taking of 500 mg calcium gluconate 2 times per day during 3 weeks the loading calciemia elimination speed increased ((1,98 ± 0,05) мкмоль/л/мин; p < 0,05) almost in two times, especially significantly ((2,23 ± 0,05 mkmol/l/min) p < 0,05) in patients with daily BP profile “night-peaker”. Mean daily BP levels decreased by (5,9 ± 1,4) % (p < 0,05), the degree of night systolic blood pressure 14 НАУЧНЫЕ ВЕДОМОСТИ у Серия: Медицина. Фармация. 2019. Том 42, No 1 lowering decreased by (4,0 ± 1,3) mm Hg (p < 0,05), brachial artery dilation in reactive hyperemia increased by 25,0 % (p < 0.05). Intensity of calcium transport between the extracellular fluid and the bone increased to (0,071 ± 0,006) mmol/min (p < 0,05), confirming slow calcium resorption from the bone tissue. The degree of bronchial obstruction decreased mainly due to large bronchi dilation by 10,0 % (small bronchi dilation was only (5,8 ± 1,9) % (p < 0,05). Ключевые слова: хроническая обструктивная болезнь легких, эссенциальная гипертензия, коррекция дефицита кальция, эндотелиальная дисфункция, функция внешнего дыхания, суточное мониторирование артериального давления.