Perspectivas imunoterapêuticas para COVID-19

Abstract

With the appearance of COVID-19, constant research on SARS-CoV-2 infection and its therapeutic prospects have begun. With an evident contribution of immunological activity to the pathogenesis of COVID-19, we highlight the main immunotherapeutic perspectives under its development. The involvement of neutrophilia and the formation of NETs (Neutrophil Extracellular Traps) is still being investigated as the clinical situation is worsening. One way to mitigate disease’s severity is by controlling neutrophil activity and the formation of NETs. Another way is to administer convalescent plasma or intravenous immunoglobulin (IgG) that can neutralize the entry of the virus into cells and modulate the immune response. However, the treatments are not yet definitive and lack favorable results.