Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin

Abstract

Human skin pigmentation results from the enzymatically-controlled synthesis of melanin pigments in specialized organelles (melanosomes) produced within epidermal melanocytes, followed by their transfer to neighboring keratinocytes and their distribution throughout the epidermis(1). Constitutive skin pigmentation seems to be mostly genetically determined(2), being altered by numerous intrinsic and extrinsic factors affecting the epidermal melanin unit(3). This article is protected by copyright. All rights reserved.