Evaluation of Cancer Bio-markers through Hyphenated Analytical Techniques

Abstract

Background: The accurate and efficient diagnosis at the early stages of cancers is the key feature for effective treatment and productive research for finding out news to types of cancers. It is essentially true for cancers, where there is no effective cure, but only one treatment is available. But most people have a combination of treatments, such as surgery with chemotherapy or radiation therapy or immunotherapy or targeted therapy or hormone therapy.Cancers symptoms of abnormal periods or pelvic pain, changes in bathroom habits, bloating, breast changes, chronic coughing, chronic headache, difficulty swallowing, excessing bruising. Despite the fact of having great need, the current availability of diagnostic tests is unable to diagnose different forms of cancers. Aim: The aim of the review is to explore the application of GC-MS, LC-MS and UP-LC/Q-TOF MS for the evaluation of changes in the biochemical composition of blood serum, urine and saliva. The power of high differentiation method will promote the translation of hyphenated techniques from a laboratory to clinical useful tool. Determination of biochemical information derives from hyphenated techniques from blood, serum, saliva and urine that will yield accurate and selective detection of cancer disorders. They will also provide diagnostic and prognostic indicators and will also play a significant role in the development of personalized medicine. Conclusion: Hyphenated techniques will allow differentiating blood serum, saliva and urine samples of common cancer disorders from normal control patients with sensitivity and specificity.