Hershberger Bioassay in Rats (H assay) (OECD TG 441) (including OECD GD 115 on the Weanling Hershberger Bioassay)

OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI:10.1787/9789264304741-21-en

引用次数: 2

Abstract

671. Modality detected/endpoints: androgens (weights of ventral prostate, seminal vesicles, LABC [levator ani plus bulbocavernosus muscle complex], cowpers glands, glans penis ↑); anti-androgens (weights of testosterone stimulated ventral prostate, seminal vesicles, LABC, cowpers glands, glans penis ↓); optional others (e.g. liver, paired kidney, paired adrenal and testis weights, changes in serum hormones including thyroid hormones). Note: weanling H assay does not include glans penis.

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大鼠Hershberger生物测定法(H测定法)(OECD TG 441)(包括OECD GD 115关于断奶鼠Hershberger生物测定法)

671. 检测形态/终点:雄激素(前列腺腹侧、精囊、LABC[提肛肌加球海绵体肌复合体]、铜腺、龟头^);抗雄激素(睾酮刺激的前列腺腹侧、精囊、LABC、铜腺、龟头↓);其他可选(如肝脏、配对肾脏、配对肾上腺和睾丸重量、血清激素包括甲状腺激素的变化)。注:断奶H检测不包括阴茎头。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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OECD Series on Testing and Assessment

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